Ultrasmall, Water-Soluble Magnetite Nanoparticles with High Relaxivity for Magnetic Resonance Imaging

被引:127
作者
Hu, Fengqin [1 ]
MacRenaris, Keith W. [1 ]
Waters, Emily A. [1 ]
Liang, Taiyang [1 ]
Schultz-Sikma, Elise A. [1 ]
Eckermann, Amanda L. [1 ]
Meade, Thomas J. [1 ]
机构
[1] Northwestern Univ, Dept Chem Biochem Mol Biol & Cell Biol Neurobiol, Evanston, IL 60208 USA
关键词
IRON-OXIDE NANOPARTICLES; NANOCRYSTALS; SIZE; COLLOIDS; MN; FE; CO;
D O I
10.1021/jp907216g
中图分类号
O64 [物理化学(理论化学)、化学物理学];
学科分类号
070304 ; 081704 ;
摘要
Ultrasmall (3, 4, 5, and 6 nm), water-soluble Fe3O4 magnetic nanoparticles were synthesized in diethylene glycol (DEG) via a facile one-pot reaction. Hydrodynamic size and relaxation time measurements did not show particle aggregation when Fe3O4 nanoparticles were dispersed in phosphate buffered saline, fetal bovine serum, or calf bovine serum for 1 week. Furthermore, the new Fe3O4 nanoparticles tolerated high salt concentrations (<= 1 M NaCl) and a wide pH range from 5 to 11. Surface modification of the nanoparticles with poly(ethylene glycol) bis(carboxymethyl) ether (HOOC-PEG-COOH, 600 g/mol) was accomplished through a ligand-exchange reaction. The effects of PEG modification on magnetization and relaxivity of the Fe3O4 nanoparticles were investigated, and the results indicate that the increase in transverse relaxivity after PEG modification may be due to the increased volume of slowly diffusing water surrounding each nanoparticle. In vitro experiments showed that the DEG- and PEG-coated Fe3O4 nanoparticles have little effect on NIH/3T3 cell viability.
引用
收藏
页码:20855 / 20860
页数:6
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