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How nucleotide excision repair protects against cancer

被引：575
作者：
Friedberg, EC [1 ]
机构：
[1] Univ Texas, SW Med Ctr, Dept Pathol, Lab Mol Pathol, Dallas, TX 75390 USA
来源：
NATURE REVIEWS CANCER | 2001年 / 1卷 / 01期
关键词：
D O I：
10.1038/35094000
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Eukaryotic cells can repair many types of DNA damage. Among the known DNA repair processes in humans, one type - nucleotide excision repair (NER) - specifically protects against mutations caused indirectly by environmental carcinogens. Humans with a hereditary defect in NER suffer from xeroderma pigmentosum and have a marked predisposition to skin cancer caused by sunlight exposure. How does NER protect against skin cancer and possibly other types of environmentally induced cancer in humans?.
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页码：22 / 33
页数：12
相关论文
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