Protective effects of ligustrazine on ischemia-reperfusion injury in rat kidneys

被引：32

作者：

Sun, LJ

Li, YJ

Shi, JS

Wang, X ^{[1
]}

机构：

[1] Fudan Univ, Dept Urol, Huashan Hosp, Sch Med, Shanghai 200040, Peoples R China

[2] Ocean Univ Qingdao, Affiliated Hosp, Dept Urol, Qingdao 266003, Peoples R China

[3] Xi An Jiao Tong Univ, Hosp 1, Lab Hepatobiliary Surg, Xian 710049, Peoples R China

来源：

MICROSURGERY | 2002年 / 22卷 / 08期

关键词：

D O I：

10.1002/micr.10058

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

To investigate the protective effects of ligustrazine on renal ischemia-reperfusion injury, the influence of ligustrazine injection on plasma superoxide dismutase (SOD), malondialdehyde (MDA), and endothelin-1 (ET-1), as well as changes of morphology of renal tubules, were studied in rat kidney models with ischemia-reperfusion injury. The results showed that in the group treated with ligustrazine, the plasma SOD level was significantly higher than that of the control group (P < 0.05), but levels of plasma MDA and ET-1 and the pathological grading of injured renal tubules were significantly lower than those in the control group (P < 0.05). These findings suggest that ligustrazine has protective effects against ischemia-reperfusion injury in rat kidneys. (C) 2002 Wiley-Liss, Inc.

引用

页码：343 / 346

页数：4

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