The Scribble and Par complexes in polarity and migration: friends or foes?

被引：118

作者：

Humbert, Patrick O. ^{[1
]}

Dow, Lukas E.

Russell, Sarah M.

机构：

[1] Peter MacCallum Canc Ctr, Cell Cycle & Canc Genet Lab, Melbourne, Vic 3002, Australia

[2] Univ Melbourne, Dept Biochem & Mol Biol, Parkville, Vic 3010, Australia

[3] Univ Melbourne, Dept Pathol, Parkville, Vic 3010, Australia

[4] Peter MacCallum Canc Ctr, Immune Signalling Lab, Melbourne, Vic 3002, Australia

[5] Swinburne Univ Technol, Fac Engn & Ind Sci, Ctr MicroPhoton, Cell Biol Lab, Hawthorn, Vic 3122, Australia

来源：

TRENDS IN CELL BIOLOGY | 2006年 / 16卷 / 12期

基金：

英国医学研究理事会; 澳大利亚研究理事会;

关键词：

D O I：

10.1016/j.tcb.2006.10.005

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The Par complex [consisting of Bazooka (also called Par3), Par6 and aPKC] is a well-described regulator of cell polarity whose role in many aspects of cell morphogenesis is under intense investigation. Recently, another set of proteins known as the Scribble complex (consisting of Scribble, Discs large and Lethal giant larvae) has also been shown to be important in polarity regulation in several settings. Here, we describe the current status of Scribble in polarity and review evidence from various model systems that indicates an essential but context-dependent role for the Scribble and Par complexes in directed cell migration. Based on the known interactions of Scribble and Par complexes with each other and with other signalling pathways, we propose models by which Par and Scribble might interact to regulate cell migration.

引用

页码：622 / 630

页数：9

共 106 条

[1] Bazooka is a permissive factor for the invasive behavior of discs large tumor cells in Drosophila ovarian follicular epithelia [J].

Abdelilah-Seyfried, S ;

Cox, DN ;

Jan, YN .

DEVELOPMENT, 2003, 130 (09) :1927-1935

[2] Dlg, Scrib and Lgl regulate neuroblast cell size and mitotic spindle asymmetry [J].

Albertson, R ;

Doe, CQ .

NATURE CELL BIOLOGY, 2003, 5 (02) :166-170

[3] Key regulators in neuronal polarity [J].

Arimura, N ;

Kaibuchi, K .

NEURON, 2005, 48 (06) :881-884

[4]

Arquier N, 2001, DEVELOPMENT, V128, P2209

[5] Mammalian scribble forms a tight complex with the βPIX exchange factor [J].

Audebert, S ;

Navarro, C ;

Nourry, C ;

Chasserot-Golaz, S ;

Lécine, P ;

Bellaiche, Y ;

Dupont, JL ;

Premont, RT ;

Sempéré, C ;

Strub, JM ;

Van Dorsselaer, A ;

Vitale, N ;

Borg, JP .

CURRENT BIOLOGY, 2004, 14 (11) :987-995

[6] The partner of inscuteable/discs-large complex is required to establish planar polarity during asymmetric cell division in Drosophila [J].

Bellaïche, Y ;

Radovic, A ;

Woods, DF ;

Hough, CD ;

Parmentier, ML ;

O'Kane, CJ ;

Bryant, PJ ;

Schweisguth, F .

CELL, 2001, 106 (03) :355-366

[7] The Par complex directs asymmetric cell division by phosphorylating the cytoskeletal protein Lgl [J].

Betschinger, J ;

Mechtler, K ;

Knoblich, JA .

NATURE, 2003, 422 (6929) :326-330

[8] Epithelial polarity and proliferation control:: links from the Drosophila neoplastic tumor suppressors [J].

Bilder, D .

GENES & DEVELOPMENT, 2004, 18 (16) :1909-1925

[9] Integrated activity of PDZ protein complexes regulates epithelial polarity [J].

Bilder, D ;

Schober, M ;

Perrimon, N .

NATURE CELL BIOLOGY, 2003, 5 (01) :53-58

[10] Localization of apical epithelial determinants by the basolateral PDZ protein Scribble [J].

Bilder, D ;

Perrimon, N .

NATURE, 2000, 403 (6770) :676-680

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