A distinct signaling pathway used by the IgG-containing B cell antigen receptor

被引:144
作者
Wakabayashi, C
Adachi, T
Wienands, R
Tsubata, T [1 ]
机构
[1] Tokyo Med & Dent Univ, Med Res Inst, Dept Immunol, Tokyo 1138510, Japan
[2] Univ Freiburg, Dept Mol Immunol Biol 3, D-79108 Freiburg, Germany
[3] Max Planck Inst Immunbiol, D-79108 Freiburg, Germany
关键词
D O I
10.1126/science.1076963
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
The immunoglobulin G (IgG)-containing B lymphocyte antigen receptor (IgG-BCR) transmits a signal distinct from that of IgM-BCR or IgD-BCR, although all three use the same signal-transducing component, Igalpha/Igbeta. Here we demonstrate that the inhibitory coreceptor CD22 down-modulates signaling through IgM-BCR and IgD-BCR, but not that through IgG-BCR, because of the IgG cytoplasmic tail, which prevents CD22 phosphorylation. These results suggest that the cytoplasmic tail of IgG specifically enhances IgG-BCR signaling by preventing CD22-mediated signal inhibition. Enhanced signaling through IgG-BCR may be involved in efficient IgG production, which is crucial for immunity to pathogens.
引用
收藏
页码:2392 / 2395
页数:5
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