Leptin increases energy expenditure and selectively promotes fat metabolism in ob/ob mice

被引：178

作者：

Hwa, JJ ^{[1
]}

Fawzi, AB ^{[1
]}

Graziano, MP ^{[1
]}

Ghibaudi, L ^{[1
]}

Williams, P ^{[1
]}

VanHeek, M ^{[1
]}

Davis, H ^{[1
]}

Rudinski, M ^{[1
]}

Sybertz, E ^{[1
]}

Strader, CD ^{[1
]}

机构：

[1] SCHERING PLOUGH CORP, INST RES, DEPT CENT NERVOUS SYST & CARDIOVASC RES, KENILWORTH, NJ 07033 USA

来源：

AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY | 1997年 / 272卷 / 04期

关键词：

leptin; thermogenesis; energy metabolism; obesity; indirect calorimetry; respiratory quotient; food intake;

D O I：

10.1152/ajpregu.1997.272.4.R1204

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Obesity occurs whenever energy intake exceeds energy expenditure. The ob gene product leptin is a potent anorectic agent when administered to ob lob mice, but its effects on energy expenditure have not been investigated in detail. The present study was designed to analyze the acute metabolic effects of leptin in vivo. Analysis of oxygen consumption in ob/ob mice demonstrated a reduction in energy expenditure compared with lean controls; this reduction showed a diurnal fluctuation and was most evident during the light cycle. A single intraperitoneal dose of leptin increased oxygen consumption during the light cycle in ob/ob mice, ablating the circadian fluctuation in this parameter. In addition, leptin had a profound effect on fuel selection: the respiratory quotient was markedly reduced, indicating a reduction in carbohydrate oxidation and an increase in fat oxidation. These acute effects of leptin on metabolic parameters are consistent with the selective loss of body fat observed on chronic leptin treatment and suggest that increased energy utilization plays an important role in the anti-obese actions of leptin.

引用

页码：R1204 / R1209

页数：6

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