Antiviral activity of arylnaphthalene and aryldihydronaphthalene lignans

被引：60

作者：

Cow, C ^{[1
]}

Leung, C ^{[1
]}

Charlton, JL ^{[1
]}

机构：

[1] Univ Manitoba, Dept Chem, Winnipeg, MB R3T 2N2, Canada

来源：

CANADIAN JOURNAL OF CHEMISTRY-REVUE CANADIENNE DE CHIMIE | 2000年 / 78卷 / 05期

关键词：

lignan; Stobbe; arylnaphthalene; antiviral;

D O I：

10.1139/cjc-78-5-553

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A practical method for large scale synthesis of 1-arylnaphthalene and 1-aryl-1,2-dihydronaphthalene lignans is described. The method makes use of the classic Stobbe condensation followed by regioselective reactions that provide access to both the common and retrolactone lignans, e.g., 2 and 3. A total of 25 compounds, many of which are known natural products, were prepared and their antiviral activity against human cytomegalovirus measured.

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页码：553 / 561

页数：9

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