Interleukin-8 and growth-regulated oncogene alpha mediate angiogenesis in Kaposi's sarcoma

被引:69
作者
Lane, BR
Liu, JG
Bock, PJ
Schols, D
Coffey, MJ
Strieter, RM
Polverini, PJ
Markovitz, DM
机构
[1] Univ Michigan, Med Ctr, Div Infect Dis, Dept Internal Med, Ann Arbor, MI 48109 USA
[2] Univ Michigan, Med Ctr, Div Pulm & Crit Care Med, Dept Internal Med, Ann Arbor, MI 48109 USA
[3] Univ Michigan, Med Ctr, Grad Program Cellular & Mol Biol, Ann Arbor, MI 48109 USA
[4] Univ Michigan, Sch Dent, Dept Oral Med Pathol & Oncol, Ann Arbor, MI 48109 USA
[5] Katholieke Univ Leuven, Rega Inst Med Res, B-3000 Louvain, Belgium
关键词
D O I
10.1128/JVI.76.22.11570-11583.2002
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
The development of the complex neoplasm Kaposi's sarcoma is dependent on infection with the Kaposi's sarcoma-associated herpesvirus (KSRV) and appears to be greatly enhanced by cytokines and human immunodeficiency virus type 1 (HIV-1) Tat. Interleukin-8 (IL-8) and growth-regulated oncogene alpha (GRO-alpha) are chemokines involved in chemoattraction, neovascularization, and stimulation of HIV-1 replication. We have previously demonstrated that production of GRO-alpha is stimulated by exposure of monocyte-derived macrophages (MDM) to HIV-1. Here we show that exposure of MDM to HIV-1, viral Tat, or viral gp120 leads to a substantial increase in IL-8 production. We also demonstrate that IL-8 and GRO-alpha are induced by KSHV infection of endothelial cells and are crucial to the angiogenic phenotype developed by KSHV-infected endothelial cells in cell culture and upon implantation into SCID mice. Thus, the three known etiological factors in Kaposi's sarcoma pathogenesis-KSHV, HIV-1 Tat, and cellular growth factors-might be linked, in part, through induction of IL-8 and GRO-alpha.
引用
收藏
页码:11570 / 11583
页数:14
相关论文
共 98 条
[1]   CC CKRS: A RANTES, MIP-1 alpha, MIP-1 beta receptor as a fusion cofactor for macrophage-tropic HIV-1 [J].
Alkhatib, G ;
Combadiere, C ;
Broder, CC ;
Feng, Y ;
Kennedy, PE ;
Murphy, PM ;
Berger, EA .
SCIENCE, 1996, 272 (5270) :1955-1958
[2]  
Ariyoshi K, 1998, J Hum Virol, V1, P193
[3]  
BAGGIOLINI M, 1994, ADV IMMUNOL, V55, P97
[4]   THE TAT PROTEIN OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1, A GROWTH-FACTOR FOR AIDS KAPOSI-SARCOMA AND CYTOKINE-ACTIVATED VASCULAR CELLS, INDUCES ADHESION OF THE SAME CELL-TYPES BY USING INTEGRIN RECEPTORS RECOGNIZING THE RGD AMINO-ACID-SEQUENCE [J].
BARILLARI, G ;
GENDELMAN, R ;
GALLO, RC ;
ENSOLI, B .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (17) :7941-7945
[5]   KAPOSIS SARCOMA AMONG PERSONS WITH AIDS - A SEXUALLY-TRANSMITTED INFECTION [J].
BERAL, V ;
PETERMAN, TA ;
BERKELMAN, RL ;
JAFFE, HW .
LANCET, 1990, 335 (8682) :123-128
[6]   A highly efficacious lymphocyte chemoattractant, stromal cell-derived factor 1 (SDF-1) [J].
Bleul, CC ;
Fuhlbrigge, RC ;
Casasnovas, JM ;
Aiuti, A ;
Springer, TA .
JOURNAL OF EXPERIMENTAL MEDICINE, 1996, 184 (03) :1101-1109
[7]   KAPOSIS SARCOMA-ASSOCIATED HERPESVIRUS INFECTS ENDOTHELIAL AND SPINDLE CELLS [J].
BOSHOFF, C ;
SCHULZ, TF ;
KENNEDY, MM ;
GRAHAM, AK ;
FISHER, C ;
THOMAS, A ;
MCGEE, JO ;
WEISS, RA ;
OLEARY, JJ .
NATURE MEDICINE, 1995, 1 (12) :1274-1278
[8]   Kaposi's sarcoma-associated herpesvirus [J].
Boshoff, C ;
Weiss, RA .
ADVANCES IN CANCER RESEARCH, VOL 75, 1998, 75 :57-86
[9]   SYNTHESIS AND STRUCTURE-ACTIVITY-RELATIONSHIPS OF PHENYLENEBIS(METHYLENE)-LINKED BIS-TETRAAZAMACROCYCLES THAT INHIBIT HIV REPLICATION - EFFECTS OF MACROCYCLIC RING SIZE AND SUBSTITUENTS ON THE AROMATIC LINKER [J].
BRIDGER, GJ ;
SKERLJ, RT ;
THORNTON, D ;
PADMANABHAN, S ;
MARTELLUCCI, SA ;
HENSON, GW ;
ABRAMS, MJ ;
YAMAMOTO, N ;
DEVREESE, K ;
PAUWELS, R ;
DECLERCQ, E .
JOURNAL OF MEDICINAL CHEMISTRY, 1995, 38 (02) :366-378
[10]  
Buchbinder Aby, 1992, Current Opinion in Oncology, V4, P867, DOI 10.1097/00001622-199210000-00009