High frequency of MIC null haplotype (HLA-B48-MICA-del-MICB*0107 N) in the Angaite Amerindian community in Paraguay

被引：21

作者：

Aida, K

Russomando, G

Kikuchi, M

Candia, N

Franco, L

Almiron, M

Ubalee, R

Hirayama, K ^{[1
]}

机构：

[1] Nagasaki Univ, Inst Trop Med, Dept Mol Immunogenet, Nagasaki 8528523, Japan

[2] Saitama Med Sch, Dept Med Zool, Moroyama, Saitama 3500495, Japan

[3] Univ Nacl Asuncion, Inst Invest Ciencias Salud, Dept Biol Mol, Asuncion, Paraguay

来源：

IMMUNOGENETICS | 2002年 / 54卷 / 06期

关键词：

deletion; MICA; MHC; HLA; haplotypes;

D O I：

10.1007/s00251-002-0485-1

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

We describe a high frequency of the MIC null haplotype, HLA-B48-MICA-del-MICB*0107 N, in the Angaite Amerindian community in Paraguay. Of the 16 unrelated subjects, 9 (56.5%) had this haplotype. The structural analyses revealed this haplotype was similar to the previously reported Asian haplotype in that they had a large-scale deletion including the entire MICA gene and linked to MICB*0107 N and HLA-B*48. The novel recombination haplotype between this MIC null haplotype and HLA-B15, HLA-B15-MICA-de;-MICB*0107 N, was also found in this community.

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收藏

页码：439 / 441

页数：3

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