Bone marrow to liver: the blood of Prometheus

被引：34

作者：

Theise, ND

Krause, DS

机构：

[1] NYU, Sch Med, Dept Pathol, New York, NY 10016 USA

[2] Yale Univ, Sch Med, Dept Lab Med, New Haven, CT 06520 USA

来源：

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 2002年 / 13卷 / 06期

关键词：

bone marrow; liver; plasticity; progenitor cells; stem cells;

D O I：

10.1016/S1084952102001283

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 [细胞生物学]; 090102 [作物遗传育种];

摘要：

The existence of hepatic stem or progenitor cells has been controversial for decades, though it was presumed that if such cells existed, they would lie within the liver. There is now consensus, however, that not only do facultative hepatic stem cells exist within the liver, but also that cells from, extra-hepatic sites, in particular the bone marrow, can contribute to hepatocyte and cholangiocyte regeneration. Despite confidence that engraftment of marrow cells in the liver occurs, the mechanistic details of this process remain poorly understood. Moreover, the physiological importance and therapeutic utility of this phenomenon remains controversial.

引用

收藏

页码：411 / 417

页数：7

相关论文

共 27 条

[1]

Cell differentiation - Hepatocytes from nonhepatic adult stem cells [J].

Alison, MR ;

Poulsom, R ;

Jeffery, R ;

Dhillon, AP ;

Quaglia, A ;

Jacob, J ;

Novelli, M ;

Prentice, G ;

Williamson, J ;

Wright, NA .

NATURE, 2000, 406 (6793) :257-257

[2]

Expression of the stem cell factor receptor c-kit in normal and diseased pediatric liver:: Identification of a human hepatic progenitor cell? [J].

Baumann, U ;

Crosby, HA ;

Ramani, P ;

Kelly, DA ;

Strain, AJ .

HEPATOLOGY, 1999, 30 (01) :112-117

[3]

Cardier JE, 1997, HEPATOLOGY, V26, P165

[4]

Entry and integration of transplanted hepatocytes in rat liver plates occur by disruption of hepatic sinusoidal endothelium [J].

Gupta, S ;

Rajvanshi, P ;

Sokhi, R ;

Slehria, S ;

Yam, A ;

Kerr, A ;

Novikoff, PM .

HEPATOLOGY, 1999, 29 (02) :509-519

[5]

Gupta S, 2000, SEMIN CANCER BIOL, V10, P161

[6]

Hepatocytes and epithelial cells of donor origin in recipients of peripheral-blood stem cells. [J].

Korbling, M ;

Katz, RL ;

Khanna, A ;

Ruifrok, AC ;

Rondon, G ;

Albitar, M ;

Champlin, RE ;

Estrov, Z .

NEW ENGLAND JOURNAL OF MEDICINE, 2002, 346 (10) :738-746

[7]

Multi-organ, multi-lineage engraftment by a single bone marrow-derived stem cell [J].

Krause, DS ;

Theise, ND ;

Collector, MI ;

Henegariu, O ;

Hwang, S ;

Gardner, R ;

Neutzel, S ;

Sharkis, SJ .

CELL, 2001, 105 (03) :369-377

[8]

Purified hematopoietic stem cells can differentiate into hepatocytes in vivo [J].

Lagasse, E ;

Connors, H ;

Al-Dhalimy, M ;

Reitsma, M ;

Dohse, M ;

Osborne, L ;

Wang, X ;

Finegold, M ;

Weissman, IL ;

Grompe, M .

NATURE MEDICINE, 2000, 6 (11) :1229-1234

[9]

Heterogeneity of the ''oval-cell'' response in the hamster liver during cholangiocarcinogenesis following Clonorchis sinensis infection and dimethylnitrosamine treatment [J].

Lee, JH ;

Rim, HJ ;

Sell, S .

JOURNAL OF HEPATOLOGY, 1997, 26 (06) :1313-1323

[10]

Bone marrow transplantation in mice leads to a minor population, of hepatocytes that can be selectively amplified in vivo [J].

Mallet, VO ;

Mitchell, C ;

Mezey, E ;

Fabre, M ;

Guidotti, JE ;

Renia, L ;

Coulombel, L ;

Kahn, A ;

Gilgenkrantz, H .

HEPATOLOGY, 2002, 35 (04) :799-804