Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak

被引：910

作者：

Willis, Simon N.

Fletcher, Jamie I.

Kaufmann, Thomas

van Delft, Mark F.

Chen, Lin

Czabotar, Peter E.

Ierino, Helen

Lee, Erinna F.

Fairlie, W. Douglas

Bouillet, Philippe

Strasser, Andreas

Kluck, Ruth M.

Adams, Jerry M.

Huang, David C. S.

机构：

[1] Walter & Eliza Hall Inst Med Res, Melbourne, Vic 3050, Australia

[2] Univ Melbourne, Dept Med Biol, Parkville, Vic 3010, Australia

来源：

SCIENCE | 2007年 / 315卷 / 5813期

基金：

英国惠康基金;

关键词：

D O I：

10.1126/science.1133289

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

A central issue in the regulation of apoptosis by the Bcl-2 family is whether its BH3-only members initiate apoptosis by directly binding to the essential cell-death mediators Bax and Bak, or whether they can act indirectly, by engaging their pro-survival Bcl-2-like relatives. Contrary to the direct-activation model, we show that Bax and Bak can mediate apoptosis without discernable association with the putative BH3-only activators (Bim, Bid, and Puma), even in cells with no Bim or Bid and reduced Puma. Our results indicate that BH3-only proteins induce apoptosis at least primarily by engaging the multiple pro-survival relatives guarding Bax and Bak.

引用

收藏

页码：856 / 859

页数：4

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