Technetium-99m nitride radiopharmaceuticals

被引：9

作者：

Duatti, A

Bolzati, C

Uccelli, L

Zucchini, GL

机构：

[1] UNIV FERRARA,DIPARTIMENTO MED CLIN & SPERIMENTALE,I-44100 FERRARA,ITALY

[2] UNIV FERRARA,DIPARTMENTO CHIM,I-44100 FERRARA,ITALY

来源：

TRANSITION METAL CHEMISTRY | 1997年 / 22卷 / 03期

关键词：

D O I：

10.1023/A:1018489113564

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Following the introduction of an efficient method for the preparation of technetium-99m complexes containing a terminal Tc=N multiple bond, under conditions suitable for nuclear medicine applications, new radiopharmaceuticals for heart and brain imaging have been discovered. These compounds belong to the class of bi-substituted, square-pyramidal nitride Tc-v complexes with dithiocarbamate ligands, and are the first examples of radiopharmaceuticals of this type exhibiting interesting biological properties, The peculiar chemical characteristics of the Tc=N core can also be conveniently utilized for the de sign of radiopharmaceuticals incorporating bioactive peptides and having definite structural features.

引用

页码：313 / 314

页数：2

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