Glycomics and disease markers

被引：231

作者：

An, Hyun Joo ^{[1
]}

Kronewitter, Scott R. ^{[1
]}

de Leoz, Maria Lorna A. ^{[1
]}

Lebrilla, Carlito B. ^{[1
,2
]}

机构：

[1] Univ Calif Davis, Dept Chem, Davis, CA 95616 USA

[2] Univ Calif Davis, Dept Biochem & Mol Med, Davis, CA 95616 USA

来源：

CURRENT OPINION IN CHEMICAL BIOLOGY | 2009年 / 13卷 / 5-6期

关键词：

PERFORMANCE LIQUID-CHROMATOGRAPHY; HEPATOCELLULAR-CARCINOMA PATIENTS; O-LINKED GLYCANS; MASS-SPECTROMETRY; N-GLYCANS; OVARIAN-CANCER; PANCREATIC-CANCER; PROSTATE-CANCER; 9-FLUORENYLMETHYL DERIVATIVES; CAPILLARY-ELECTROPHORESIS;

D O I：

10.1016/j.cbpa.2009.08.015

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Glycomics is the comprehensive study of all glycans expressed in biological systems. The biosynthesis of glycan relies on a number of highly competitive processes involving glycosyl transferases. Glycosylation is therefore highly sensitive to the biochemical environment and has been implicated in many diseases including cancer. Recently, interest in profiling the glycome has increased owing to the potential of glycans for disease markers. In this regard, mass spectrometry is emerging as a powerful technique for profiling the glycome. Global glycan profiling of human serum based on mass spectrometry has already led to several potentially promising markers for several types of cancer and diseases.

引用

收藏

页码：601 / 607

页数：7

相关论文

共 55 条

[1]

A strategy to reveal potential glycan markers from serum glycoproteins associated with breast cancer progression [J].

Abd Hamid, Umi M. ;

Royle, Louise ;

Saldova, Radka ;

Radcliffe, Catherine M. ;

Harvey, David J. ;

Storr, Sarah J. ;

Pardo, Maria ;

Antrobus, Robin ;

Chapman, Caroline J. ;

Zitzmann, Nicole ;

Robertson, John F. ;

Dwek, Raymond A. ;

Rudd, Pauline M. .

GLYCOBIOLOGY, 2008, 18 (12) :1105-1118

[2]

Glycomics analyses of tear fluid for the diagnostic detection of ocular rosacea [J].

An, HJ ;

Ninonuevo, M ;

Aguilan, J ;

Liu, H ;

Lebrilla, CB ;

Alvarenga, LS ;

Mannis, MJ .

JOURNAL OF PROTEOME RESEARCH, 2005, 4 (06) :1981-1987

[3]

Improved capillary electrophoretic separation and mass spectrometric detection of oligosaccharides [J].

An, HJ ;

Franz, AH ;

Lebrilla, CB .

JOURNAL OF CHROMATOGRAPHY A, 2003, 1004 (1-2) :121-129

[4]

Suppression of sialylated by sulfated oligosaccharides in negative MALDI-FTMS [J].

An, HJ ;

Lebrilla, CB .

ISRAEL JOURNAL OF CHEMISTRY, 2001, 41 (02) :117-127

[5]

Profiling of glycans in serum for the discovery of potential biomarkers for ovarian cancer [J].

An, Hyun Joo ;

Miyamoto, Suzanne ;

Lancaster, Katherine S. ;

Kirmiz, Crystal ;

Li, Bensheng ;

Lam, Kit S. ;

Leiserowitz, Gary S. ;

Lebrilla, Carlito B. .

JOURNAL OF PROTEOME RESEARCH, 2006, 5 (07) :1626-1635

[6]

On the frequency of protein glycosylation, as deduced from analysis of the SWISS-PROT database [J].

Apweiler, R ;

Hermjakob, H ;

Sharon, N .

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 1999, 1473 (01) :4-8

[7]

Development of a nanoLC LTQ Orbitrap Mass Spectrometric Method for Profiling Glycans Derived from Plasma from Healthy, Benign Tumor Control, and Epithelial Ovarian Cancer Patients [J].

Bereman, Michael S. ;

Williams, Taufika Islam ;

Muddiman, David C. .

ANALYTICAL CHEMISTRY, 2009, 81 (03) :1130-1136

[8]

Glycomic Analysis of N-Linked Carbohydrate Epitopes from CD24 of Mouse Brain [J].

Bleckmann, Christina ;

Geyer, Hildegard ;

Reinhold, Vernon ;

Lieberoth, Annika ;

Schachner, Melitta ;

Kleene, Ralf ;

Geyer, Rudolf .

JOURNAL OF PROTEOME RESEARCH, 2009, 8 (02) :567-582

[9]

Quantification by isobaric labeling (QUIBL) for the comparative glycomic study of O-linked glycans [J].

Botelho, Julianne Cook ;

Atwood, James A., III ;

Cheng, Lei ;

Alvarez-Manilla, Gerardo ;

York, William S. ;

Orlando, Ron .

INTERNATIONAL JOURNAL OF MASS SPECTROMETRY, 2008, 278 (2-3) :137-142

[10]

Profile of native N-linked glycan structures from human serum using high performance liquid chromatography on a microfluidic chip and time-of-flight mass spectrometry [J].

Chu, Caroline S. ;

Ninonuevo, Milady R. ;

Clowers, Brian H. ;

Perkins, Patrick D. ;

An, Hyun Joo ;

Yin, Hongfeng ;

Killeen, Kevin ;

Miyamoto, Suzanne ;

Grimm, Rudolf ;

Lebrilla, Carlito B. .

PROTEOMICS, 2009, 9 (07) :1939-1951

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