Interferon-alfa, interferon-λ and hepatitis C

被引:58
作者
O'Brien, Thomas R. [1 ]
机构
[1] NCI, Div Canc Epidemiol & Genet, NIH, Dept Hlth & Human Serv, Bethesda, MD 20892 USA
关键词
VIRUS-REPLICATION; INFECTION; PEGINTERFERON; RIBAVIRIN; IL-29;
D O I
10.1038/ng.453
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
Three new studies report genetic variants near IL28B, which encodes interferon-lambda 3 (interleukin 28B), are associated with response to treatment of chronic hepatitis C virus infection with interferon-alfa/ribavirin combination therapy. This renews interest in how interferons suppress viremia and could lead to improved clinical decisions for chronic HCV infection treatment based on individual genotype.
引用
收藏
页码:1048 / 1050
页数:4
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