Identification of morphine in the rat adrenal gland

被引：39

作者：

Goumon, Y ^{[1
]}

Stefano, GB ^{[1
]}

机构：

[1] SUNY Coll Old Westbury, Neurosci Res Inst, Old Westbury, NY 11568 USA

来源：

MOLECULAR BRAIN RESEARCH | 2000年 / 77卷 / 02期

关键词：

rat; endogenous morphine; adrenal gland;

D O I：

10.1016/S0169-328X(00)00056-5

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Morphine was identified in rat adrenal extracts by reverse-phase HPLC, following liquid and solid extraction. All experiments were carefully performed to prevent exogenous morphine contamination. The morphine extracted from adrenal tissue (105.31 ng/g of wet adrenal gland) was identical to that of a morphine internal standard. The morphine corresponding HPLC fractions were further analyzed by gas chromatography-mass spectrometry and found to be identical to synthetic morphine. The study conclusively proves morphine is endogenous to the rat adrenal gland. (C) 2000 Elsevier Science B.V. All rights reserved.

引用

页码：267 / 269

页数：3

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