Serotonin regulates hippocampal glucocorticoid receptor expression via a 5-HT7 receptor

被引：97

作者：

Laplante, P

Diorio, J

Meaney, MJ

机构：

[1] McGill Univ, Dept Psychiat, Dev Neuroendocrinol Lab, Douglas Hosp,Res Ctr, Verdun, PQ H4H 1R3, Canada

[2] McGill Univ, Dept Neurol & Neurosurg, Dev Neuroendocrinol Lab, Douglas Hosp,Res Ctr, Verdun, PQ H4H 1R3, Canada

来源：

DEVELOPMENTAL BRAIN RESEARCH | 2002年 / 139卷 / 02期

基金：

加拿大健康研究院;

关键词：

glucocorticoid receptor; serotonin; serotonin-7; receptor; cAMP; hippocampus;

D O I：

10.1016/S0165-3806(02)00550-3

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Glucocorticoid receptor expression in primary hippocampal cell cultures was significantly increased with either 10 mM 8-bromo cAMP, 50 nM 5-carboxamidotryptamine (5-CT), a potent 5-HT7 receptor agonist, or 100 nM 5-HT. The effect of 5-HT or 5-CT was blocked with methiothepin or by a protein kinase A inhibitor, but not pindolol. These results suggest that the effects of 5-HT on hippocampal GR expression is mediated by a 5-HT7 receptor. (C) 2002 Elsevier Science B.V. All rights reserved.

引用

页码：199 / 203

页数：5

共 31 条

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