Nuclear structure and DNA replication

被引：41

作者：

DePamphilis, ML ^{[1
]}

机构：

[1] NICHHD, NIH, Bethesda, MD 20892 USA

来源：

JOURNAL OF STRUCTURAL BIOLOGY | 2000年 / 129卷 / 2-3期

关键词：

eukaryotic DNA replication; nucleus; nuclear structure; nuclear matrix; nucleoskeleton; origin recognition complex; cell cycle;

D O I：

10.1006/jsbi.2000.4219

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

DNA replication is a highly conserved process among eukaryotes where it occurs within a unique organelle-the nucleus. The importance of this structure is indicated by the fact that assembly of prereplication complexes on cellular chromatin is delayed until mitosis is completed and a nuclear structure has formed. Although nuclear structure is dispensable for DNA replication in vitro, it does appear to play a role in vivo by regulating the concentration of proteins required to initiate DNA replication, by facilitating the assembly or activity of DNA replication forks, and by determining where in the genome initiation of DNA replication occurs.

引用

页码：186 / 197

页数：12

共 108 条

[1] Cell cycle modulation of protein-DNA interactions at a human replication origin [J].

Abdurashidova, G ;

Riva, S ;

Biamonti, G ;

Giacca, M ;

Falaschi, A .

EMBO JOURNAL, 1998, 17 (10) :2961-2969

[2] STUDY OF THE CELL CYCLE-DEPENDENT ASSEMBLY OF THE DNA PRE-REPLICATION CENTERS IN XENOPUS EGG EXTRACTS [J].

ADACHI, Y ;

LAEMMLI, UK .

EMBO JOURNAL, 1994, 13 (17) :4153-4164

[3] Genetic dissection of a mammalian replicator in the human β-globin locus [J].

Aladjem, MI ;

Rodewald, LW ;

Kolman, JL ;

Wahl, GM .

SCIENCE, 1998, 281 (5379) :1005-1009

[4] PARTICIPATION OF THE HUMAN BETA-GLOBIN LOCUS-CONTROL REGION IN INITIATION OF DNA-REPLICATION [J].

ALADJEM, MI ;

GROUDINE, M ;

BRODY, LL ;

DIEKEN, ES ;

FOURNIER, REK ;

WAHL, GM ;

EPNER, EM .

SCIENCE, 1995, 270 (5237) :815-819

[5] Differential assembly of Cdc45p and DNA polymerases at early and late origins of DNA replication [J].

Aparicio, OM ;

Stout, AM ;

Bell, SP .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (16) :9130-9135

[6] Drosophila ORC specifically binds to ACE3, an origin of DNA replication control element [J].

Austin, RJ ;

Orr-Weaver, TL ;

Bell, SP .

GENES & DEVELOPMENT, 1999, 13 (20) :2639-2649

[7] Semi-conservative replication in yeast nuclear extracts requires DNA2 helicase and supercoiled template [J].

Braguglia, D ;

Heun, P ;

Pasero, P ;

Duncker, BP ;

Gasser, SM .

JOURNAL OF MOLECULAR BIOLOGY, 1998, 281 (04) :631-649

[8]

Cardoso MC, 1998, J CELL BIOCHEM, V70, P222, DOI 10.1002/(SICI)1097-4644(19980801)70:2<222::AID-JCB8>3.3.CO

[9]

2-R

[10] Identification of a novel 81-kDa component of the Xenopus origin recognition complex [J].

Carpenter, PB ;

Dunphy, WG .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (38) :24891-24897

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