Intracellular parasitism by the human granulocytic ehrlichiosis bacterium through the P-selectin ligand, PSGL-1

被引:105
作者
Herron, MJ
Nelson, CM
Larson, J
Snapp, KR
Kansas, GS
Goodman, JL [1 ]
机构
[1] Univ Minnesota, Sch Med, Dept Med, Div Infect Dis, Minneapolis, MN 55455 USA
[2] Northwestern Univ, Sch Med, Dept Microbiol Immunol, Chicago, IL 60611 USA
关键词
D O I
10.1126/science.288.5471.1653
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Human granulocytic ehrlichiosis (HGE) is a febrile tick-borne illness caused by a recently discovered intracellular bacterium remarkable for its tropism for professionally phagocytic neutrophils. Monoclonal antibodies against the P-selectin binding domain of the leukocyte P-selectin glycoprotein ligand, PSGL-1, prevented HGE cell binding and infection, as did enzymatic digestion of PSGL-1. Furthermore, simultaneous neoexpression in nonsusceptible cells of complementary DNAs for both PSGL-1 and its modifying alpha-(1,3) fucosyltransferase, Fuc-TVII, allowed binding and infection by HGE. Thus, the HGE bacterium specifically bound to fucosylated Leukocyte PSGL-1. Selectin mimicry is likely central to the organism's unique ability to target and infect neutrophils.
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页码:1653 / 1656
页数:4
相关论文
共 28 条
[1]  
Behl R, 2000, THROMB HAEMOSTASIS, V83, P114
[2]   SELECTINS [J].
BEVILACQUA, MP ;
NELSON, RM .
JOURNAL OF CLINICAL INVESTIGATION, 1993, 91 (02) :379-387
[3]   MACROPHAGE COMPLEMENT AND LECTIN-LIKE RECEPTORS BIND LEISHMANIA IN THE ABSENCE OF SERUM [J].
BLACKWELL, JM ;
EZEKOWITZ, RAB ;
ROBERTS, MB ;
CHANNON, JY ;
SIM, RB ;
GORDON, S .
JOURNAL OF EXPERIMENTAL MEDICINE, 1985, 162 (01) :324-331
[4]   SIGNAL-TRANSDUCTION IN THE MAMMALIAN-CELL DURING BACTERIAL ATTACHMENT AND ENTRY [J].
BLISKA, JB ;
GALAN, JE ;
FALKOW, S .
CELL, 1993, 73 (05) :903-920
[5]   IDENTIFICATION OF A GRANULOCYTOTROPIC EHRLICHIA SPECIES AS THE ETIOLOGIC AGENT OF HUMAN-DISEASE [J].
CHEN, SM ;
DUMLER, JS ;
BAKKEN, JS ;
WALKER, DH .
JOURNAL OF CLINICAL MICROBIOLOGY, 1994, 32 (03) :589-595
[6]   Cellular microbiology emerging [J].
Cossart, P ;
Boquet, P ;
Normark, S ;
Rappuoli, R .
SCIENCE, 1996, 271 (5247) :315-316
[7]   LAMININ ON TOXOPLASMA-GONDII MEDIATES PARASITE BINDING TO THE BETA-1 INTEGRIN RECEPTOR ALPHA-6-BETA-1 ON HUMAN FORESKIN FIBROBLASTS AND CHINESE-HAMSTER OVARY CELLS [J].
FURTADO, GD ;
CAO, Y ;
JOINER, KA .
INFECTION AND IMMUNITY, 1992, 60 (11) :4925-4931
[8]   Leukocyte infection by the granulocytic ehrlichiosis agent is linked to expression of a selectin ligand [J].
Goodman, JL ;
Nelson, CM ;
Klein, MB ;
Hayes, SF ;
Weston, BW .
JOURNAL OF CLINICAL INVESTIGATION, 1999, 103 (03) :407-412
[9]   Direct cultivation of the causative agent of human granulocytic ehrlichiosis [J].
Goodman, JL ;
Nelson, C ;
Vitale, B ;
Madigan, JE ;
Dumler, JS ;
Kurtti, TJ ;
Munderloh, UG .
NEW ENGLAND JOURNAL OF MEDICINE, 1996, 334 (04) :209-215
[10]   Engagement of P-selectin glycoprotein ligand-1 enhances tyrosine phosphorylation and activates mitogen-activated protein kinases in human neutrophils [J].
Hidari, KIPJ ;
Weyrich, AS ;
Zimmerman, GA ;
McEver, RP .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (45) :28750-28756