Connecting obesity, aging and diabetes

被引：209

作者：

Ahima, Rexford S. ^{[1
]}

机构：

[1] Univ Penn, Sch Med, Inst Diabet Obes & Metab, Div Endocrinol Diabet & Metab,Dept Med, Philadelphia, PA 19104 USA

来源：

NATURE MEDICINE | 2009年 / 15卷 / 09期

关键词：

INSULIN-RESISTANCE; INFLAMMATION; DISEASE;

D O I：

10.1038/nm0909-996

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Obesity accelerates the aging of adipose tissue, a process only now beginning to come to light at the molecular level. Experiments in mice suggest that obesity increases the formation of reactive oxygen species in fat cells, shortens telomeres—and ultimately results in activation of the p53 tumor suppressor, inflammation and the promotion of insulin resistance (pages 1082–1087).

引用

页码：996 / 997

页数：3

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