HIV antibodies: Further questions and a plea for clarification

被引:6
作者
PapadopulosEleopulos, E
Turner, VF
Papadimitriou, JM
Stewart, G
Causer, D
机构
[1] ROYAL PERTH HOSP,DEPT EMERGENCY MED,PERTH,WA 6001,AUSTRALIA
[2] UNIV WESTERN AUSTRALIA,NEDLANDS,WA 6009,AUSTRALIA
[3] UNIV GLASGOW,GLASGOW G12 8QQ,LANARK,SCOTLAND
关键词
AIDS; antibodies; HIV; HL23V; isolation; infection; mannans mycobacteria; retroviruses; specificity; yeasts;
D O I
10.1185/03007999709113336
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The existence of specific antibody/protein reactions is the crucial assumption underlying proof of HIV isolation, proof of HIV infection and the causative role of HIV in AIDS. However, since 1. antibodies which react with the 'HIV' proteins arise following allogenic stimuli in non-HIV-infected animals and humans, as well as in mice and humans with autoimmune disorders; antibodies to antigens from both mycobacteria and yeasts cross-react with HIV env and gag proteins; 2. individuals belonging to the AIDS risk groups are subjected to allogenic stimuli and have high levels of autoimmune antibodies, while the vast majority of patients in the AIDS risk groups are infected with either or both mycobacteria or yeasts, the evidence for the existence of HIV and its putative role in AIDS must be reappraised.
引用
收藏
页码:627 / 634
页数:8
相关论文
共 28 条
[1]   HUMANS HAVE ANTIBODIES CAPABLE OF RECOGNIZING ONCOVIRAL GLYCOPROTEIN - DEMONSTRATION THAT THESE ANTIBODIES ARE FORMED IN RESPONSE TO CELLULAR MODIFICATION OF GLYCOPROTEINS RATHER THAN AS CONSEQUENCE OF EXPOSURE TO VIRUS [J].
BARBACID, M ;
BOLOGNESI, D ;
AARONSON, SA .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1980, 77 (03) :1617-1621
[2]   MALE-HOMOSEXUAL TRANSMISSION OF HIV-1 [J].
CACERES, CF ;
VANGRIENSVEN, GJP .
AIDS, 1994, 8 (08) :1051-1061
[4]   UPTAKE OF PNEUMOCYSTIS-CARINII MEDIATED BY THE MACROPHAGE MANNOSE RECEPTOR [J].
EZEKOWITZ, RAB ;
WILLIAMS, DJ ;
KOZIEL, H ;
ARMSTRONG, MYK ;
WARNER, A ;
RICHARDS, FF ;
ROSE, RM .
NATURE, 1991, 351 (6322) :155-158
[5]   Epitope specificity of anti-HIV antibodies in human and murine autoimmune diseases [J].
Fraziano, M ;
Montesano, C ;
Lombardi, VRM ;
Sammarco, I ;
DePisa, F ;
Mattei, M ;
Valesini, G ;
Pittoni, V ;
Colizzi, V .
AIDS RESEARCH AND HUMAN RETROVIRUSES, 1996, 12 (06) :491-496
[6]   TYPE C RNA TUMOR-VIRUS ISOLATED FROM CULTURED HUMAN ACUTE MYELOGENOUS LEUKEMIA-CELLS [J].
GALLAGHER, RE ;
GALLO, RC .
SCIENCE, 1975, 187 (4174) :350-353
[7]  
GALLO RC, 1986, NATURE, V321, P119, DOI 10.1038/321119a0
[8]  
GALLO RC, 1976, ANIMAL VIROLOGY, P385
[9]   FINE-STRUCTURE OF HUMAN IMMUNODEFICIENCY VIRUS (HIV), IMMUNOLOCALIZATION OF STRUCTURAL PROTEINS AND VIRUS-CELL RELATION [J].
GELDERBLOM, HR ;
OZEL, M ;
HAUSMANN, EHS ;
WINKEL, T ;
PAULI, G ;
KOCH, MA .
MICRON AND MICROSCOPICA ACTA, 1988, 19 (01) :41-60
[10]  
HOFFMAN OA, 1993, J IMMUNOL, V150, P3932