Plasma deoxycholic acid is related to deoxycholic acid in faecal water

被引：10

作者：

vanFaassen, A

Ochsenkuhn, T

Houterman, S

vanderPloeg, EMC

BuenodeMesquita, BH

Ocke, MC

Bayerdorffer, E

Janknegt, RA

机构：

[1] UNIV MUNICH,DEPT INTERNAL MED 2,KLINIKUM GROSSHADERN,D-81377 MUNCHEBERG,GERMANY

[2] UNIV HOSP,DEPT DIETET,MAASTRICHT,NETHERLANDS

[3] NATL INST PUBL HLTH & ENVIRONM,DEPT CHRON DIS & ENVIRONM EPIDEMIOL,NL-3720 BA BILTHOVEN,NETHERLANDS

来源：

CANCER LETTERS | 1997年 / 114卷 / 1-2期

关键词：

bile acids; colorectal cancer; diet;

D O I：

10.1016/S0304-3835(97)04683-1

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Bile acids are considered as a risk factor for colorectal carcinogenesis. They were analysed in samples of faecal water and plasma of fasting heparine blood from 23 urorithiasis patients. Linear regression showed that the highest percentage of variance (52%) was explained by the model: plasma deoxycholic acid (mu mol/l) = - 3.11 + 0.96(+/- 0.25*) (10)log deoxycholic acid in faecal water (mu mol/l) + 0.35(+/- 0.15*) pH of faecal water - 0.41(+/- 0.19*) defacation frequency (number of stools/day); *P < 0.05, *P = 0.055. In future studies, analysing blood levels of unconjugated deoxycholic acid may substitute faecal measurements. (C) 1997 Elsevier Science Ireland Ltd.

引用

页码：293 / 294

页数：2

共 4 条

[1] UNCONJUGATED SECONDARY BILE-ACIDS IN THE SERUM OF PATIENTS WITH COLORECTAL ADENOMAS [J].

BAYERDORFFER, E ;

MANNES, GA ;

OCHSENKUHN, T ;

DIRSCHEDL, P ;

WIEBECKE, B ;

PAUMGARTNER, G .

GUT, 1995, 36 (02) :268-273

[2] FECAL UNCONJUGATED BILE-ACIDS IN PATIENTS WITH COLORECTAL-CANCER OR POLYPS [J].

IMRAY, CHE ;

RADLEY, S ;

DAVIS, A ;

BARKER, G ;

HENDRICKSE, CW ;

DONOVAN, IA ;

LAWSON, AM ;

BAKER, PR ;

NEOPTOLEMOS, JP .

GUT, 1992, 33 (09) :1239-1245

[3] A RANDOMIZED TRIAL OF A LOW-FAT HIGH-FIBER DIET IN THE RECURRENCE OF COLORECTAL POLYPS [J].

MCKEOWNEYSSEN, GE ;

BRIGHTSEE, E ;

BRUCE, WR ;

JAZMAJI, V ;

COLE, LJ ;

FEINMAN, SV ;

MYERS, ED ;

NEWMAN, A ;

STERN, HS ;

HAMILTON, JD ;

RUDD, WWH ;

RUDERMAN, RL ;

MOORE, TL ;

OTTAWAY, CA ;

PROKIPUCHUK, EJ ;

COHEN, Z ;

GREENBERG, GR ;

JEEJEBHOY, KN ;

MCLEOD, RS ;

TAYLOR, BR ;

WOLMAN, SL ;

BAKER, JP ;

HIMAL, HS ;

MATHEWS, RE ;

MCHUGH, SM ;

STONE, RM ;

WEIZEL, HAE ;

WRIGHT, JR ;

HABER, GB ;

JAMIESON, CR ;

KORTAN, P ;

MACKENZIE, RL ;

MARCON, NE ;

MURTHI, MST ;

RICHARDSON, BJ ;

ROSS, TM ;

STAFFORD, SE ;

PTAK, TW .

JOURNAL OF CLINICAL EPIDEMIOLOGY, 1994, 47 (05) :525-536

[4]

VANFAASSEN A, 1993, AM J CLIN NUTR, V58, P917

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