Isolation of erinacine P, a new parental metabolite of cyathane-xylosides, from Hericium erinaceum and its biomimetic conversion into erinacines A and B

被引：112

作者：

Kenmoku, H

Sassa, T ^{[1
]}

Kato, N

机构：

[1] Yamagata Univ, Fac Agr, Dept Bioresources, Yamagata 9978555, Japan

[2] Kyushu Univ, Inst Adv Mat Study, Kasuga, Fukuoka 8168580, Japan

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 22期

关键词：

biomimetic reactions; biosynthesis; glycosides; terpenes and terpenoids;

D O I：

10.1016/S0040-4039(00)00601-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 [有机化学]; 081704 [应用化学];

摘要：

A new cyathane-xyloside, erinacine P, was isolated from mycelia of basidiomycetous Hericium erinaceum YB4-6237 in a shaken culture. Since its aglycon closely resembles typical cyathane diterpenoids such as cyathins and cyathatriols in its substitution pattern, this glycoside seems to be an important metabolite in the biosynthesis of erinacines and striatins. In fact, according to our biogenesis studies, erinacine P can be successfully converted chemically into erinacine B and, further, to erinacine A under mild conditions. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：4389 / 4393

页数：5

共 16 条

[1]

Ayer W. A., 1978, REV LATINOAM QUIM, V9, P177

[2]

METABOLITES OF BIRDS NEST FUNGI .11. DITERPENOID METABOLITES OF CYATHUS-EARLEI LLOYD [J].