The trophoblast is a component of the innate immune system during pregnancy

被引:148
作者
Guleria, I
Pollard, JW
机构
[1] Yeshiva Univ Albert Einstein Coll Med, Dept Dev, Bronx, NY 10461 USA
[2] Yeshiva Univ Albert Einstein Coll Med, Dept Obstet & Gynecol, Bronx, NY 10461 USA
[3] Yeshiva Univ Albert Einstein Coll Med, Dept Mol Biol, Bronx, NY 10461 USA
[4] Yeshiva Univ Albert Einstein Coll Med, Dept Womens Hlth, Bronx, NY 10461 USA
关键词
D O I
10.1038/75074
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Systemic infection with Listeria monocytogenes, a Gram-positive intracellular bacterium, has been used extensively to analyze the innate immune response(1,2). Macrophages are central to this response, acting as both the host for and principal defense against this bacterium. During pregnancy L. monocytogenes has a predilection for replication at the maternal-placental interface and consequently is an important cause of fetal morbidity and mortality(3,4). However, macrophages are mostly excluded from the murine placenta with neutrophils acting as the main immune effector cell against this bacterium(3,5,6). Colony stimulating factor (CSF)-1, a macrophage growth factor, is synthesized in high concentrations by the uterine epithelium during pregnancy, where it is targeted to trophoblast bearing CSF-1-receptors(7,8). To define the involvement of CSF-1 in placental immunity, we infected pregnant mice either homozygous or heterozygous for an inactivating recessive mutation in the gene for CSF-1 (osteopetrotic; Csfm(op)) with L. monocytogenes(9). CSF-1 was required to recruit neutrophils to the site of listerial infection in the decidua basalis, and infection by Listeria remained unrestrained in its absence. CSF-1 acted by inducing the trophoblast to synthesize the neutrophil chemoattractants (KC) and macrophage inflammatory protein (MIP)-2. Thus, during pregnancy, trophoblast responsive to CSF-1 acts to organize the maternal immune response to bacterial infection at the utero-placental interface. This previously unknown function indicates that the trophoblast acts as a pregnancy-specific component of the innate immune system.
引用
收藏
页码:589 / 593
页数:5
相关论文
共 23 条
[1]   TEMPORAL EXPRESSION AND LOCATION OF COLONY-STIMULATING FACTOR-I (CSF-1) AND ITS RECEPTOR IN THE FEMALE REPRODUCTIVE-TRACT ARE CONSISTENT WITH CSF-1-REGULATED PLACENTAL DEVELOPMENT [J].
ARCECI, RJ ;
SHANAHAN, F ;
STANLEY, ER ;
POLLARD, JW .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (22) :8818-8822
[2]   Interferon-γ contributes to the normalcy of murine pregnancy [J].
Ashkar, AA ;
Croy, BA .
BIOLOGY OF REPRODUCTION, 1999, 61 (02) :493-502
[3]  
BAGGIOLINI M, 1994, ADV IMMUNOL, V55, P97
[4]  
CECCHINI MG, 1994, DEVELOPMENT, V120, P1357
[5]   THE TROPHOBLAST AS AN INTEGRAL COMPONENT OF A MACROPHAGE CYTOKINE NETWORK [J].
GUILBERT, L ;
ROBERTSON, SA ;
WEGMANN, TG .
IMMUNOLOGY AND CELL BIOLOGY, 1993, 71 :49-57
[6]   IMMUNITY TO INTRACELLULAR BACTERIA [J].
KAUFMANN, SHE .
ANNUAL REVIEW OF IMMUNOLOGY, 1993, 11 :129-163
[7]   A STUDY OF GRANULATED METRIAL GLAND CELL-DIFFERENTIATION IN PREGNANT, MACROPHAGE-DEFICIENT, OSTEOPETROTIC (OP/OP) MICE [J].
KISO, Y ;
POLLARD, JW ;
CROY, BA .
EXPERIENTIA, 1992, 48 (10) :973-975
[8]   Listeriosis [J].
Lorber, B .
CLINICAL INFECTIOUS DISEASES, 1997, 24 (01) :1-11
[9]  
LU CY, 1991, MOLECULAR AND CELLULAR IMMUNOBIOLOGY OF THE MATERNAL FETAL INTERFACE, P141
[10]   GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR IS NOT RESPONSIBLE FOR THE CORRECTION OF HEMATOPOIETIC DEFICIENCIES IN THE MATURING OP/OP MOUSE [J].
NILSSON, SK ;
LIESCHKE, GJ ;
GARCIAWIJNEN, CC ;
WILLIAMS, B ;
TZELEPIS, D ;
HODGSON, G ;
GRAIL, D ;
DUNN, AR ;
BERTONCELLO, I .
BLOOD, 1995, 86 (01) :66-72