A novel combination of four flavonoids derived from Astragali Radix relieves the symptoms of cyclophosphamide-induced anemic rats

被引：42

作者：

Zhang, Li ^{[1
,2
,3
]}

Gong, Amy G. W. ^{[1
,2
]}

Riaz, Kashif ^{[4
]}

Deng, Jun Y. ^{[1
,2
]}

Ho, Chih M. ^{[5
]}

Lin, Huang Q. ^{[1
,2
,6
]}

Dong, Tina T. X. ^{[1
,2
,6
]}

Lee, Yi-Kuen ^{[4
]}

Tsim, Karl W. K. ^{[1
,2
,6
]}

机构：

[1] Hong Kong Univ Sci & Technol, Div Life Sci, Clear Water Bay Rd, Hong Kong, Hong Kong, Peoples R China

[2] Hong Kong Univ Sci & Technol, Ctr Chinese Med, Hong Kong, Hong Kong, Peoples R China

[3] Shanghai Univ Tradit Chinese Med, Sch Pharm, Shanghai, Peoples R China

[4] Hong Kong Univ Sci & Technol, Dept Mech & Aerosp Engn, Hong Kong, Hong Kong, Peoples R China

[5] Univ Calif Los Angeles, Dept Mech & Aerosp Engn, Los Angeles, CA USA

[6] HKUST Shenzhen Res Inst, Shenzhen, Guangdong, Peoples R China

来源：

FEBS OPEN BIO | 2017年 / 7卷 / 03期

关键词：

feedback system control; flavonoids combination; hematological parameters; RECOMBINANT-HUMAN-ERYTHROPOIETIN; CHEMOTHERAPY-INDUCED ANEMIA; CHINESE HERBAL DECOCTION; DANGGUI BUXUE TANG; ANGELICAE-SINENSIS; FOLLOW-UP; CELLS; INFECTION; DISEASE; KIDNEY;

D O I：

10.1002/2211-5463.12146

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

By using a feedback system control scheme, the best combination of formononetin, ononin, calycosin, and calycosin-7-O-beta-D-glucoside derived from Astragali Radix was shown to activate a hypoxia response element, a regulator for erythropoietin (EPO) transcription, in kidney fibroblast. In cyclophosphamide-induced anemic rats, the treatment of combined flavonoids, or EPO, improved the levels of red blood cells, white blood cells, hemoglobin, and hematocrit. In addition, the altered levels of antioxidant capacity, super oxidase dismutase, and malondialdehyde, triggered in anemic rats, were restored to control levels by the treatment of flavonoids. Here, we proposed a possible therapy by using the common flavonoids in treating anemia.

引用

页码：318 / 323

页数：6

共 30 条

[1]

Anaemia and congestive heart failure early post-renal transplantation [J].