Emerging Role for Members of the Bcl-2 Family in Mitochondrial Morphogenesis

被引：257

作者：

Autret, Arnaud ^{[1
]}

Martin, Seamus J. ^{[1
]}

机构：

[1] Trinity Coll Dublin, Dept Genet, Smurfit Inst, Mol Cell Biol Lab, Dublin 2, Ireland

来源：

MOLECULAR CELL | 2009年 / 36卷 / 03期

基金：

爱尔兰科学基金会;

关键词：

CYTOCHROME-C; SYNAPSE FORMATION; FISSION; APOPTOSIS; FUSION; BAX; PROTEINS; RELEASE; CELLS; CED-9;

D O I：

10.1016/j.molcel.2009.10.011

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Bcl-2 family proteins regulate apoptosis by controlling the release of mitochondrial cytochrome c via the Bax/Bak channel. However, recent studies have also implicated several members of this family in the regulation of mitochondrial fission/fusion dynamics. It has been debated whether the role of Bcl-2 proteins in mitochondrial morphogenesis is functionally distinct from their role in apoptosis, with some arguing that Bax/Bak-induced mitochondrial fission promotes apoptosis-associated cytochrome c release, while others suggest that these functions are separable. Here we review this emerging area and argue for a role for the Bcl-2 family as novel regulators of mitochondrial morphogenesis. © 2009 Elsevier Inc. All rights reserved.

引用

页码：355 / 363

页数：9

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