Tissue engineering and the development of Apligraf(R), a human skin equivalent

被引：104

作者：

Eaglstein, WH ^{[1
]}

Falanga, V ^{[1
]}

机构：

[1] UNIV MIAMI, SCH MED, DEPT DERMATOL & CUTANEOUS SURG, MIAMI, FL 33152 USA

来源：

CLINICAL THERAPEUTICS | 1997年 / 19卷 / 05期

关键词：

wounds; skin equivalent; tissue engineering; Apligraf;

D O I：

10.1016/S0149-2918(97)80043-4

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

In recent years, skin grafting has evolved from the initial autograft and allograft preparations to biosynthetic and tissue-engineered living skin replacements. This review details the pioneering work of numerous investigators that led to the following precursors of tissue-engineered skin replacement: cultured autologous keratinocyte grafts, cultured allogeneic keratinocyte grafts, autologous/allogeneic composites, acellular collagen matrices, and cellular matrices. It also discusses the rationale for the development of the newer products and describes the technical advances leading to the development of Apligraf(R), a tissue-engineered human skin product.

引用

页码：894 / 905

页数：12

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