Controlling influenza virus replication by inhibiting its proton channel

被引：77

作者：

Pinto, Lawrence H.

Lamb, Robert A.

机构：

[1] Northwestern Univ, Dept Neurobiol & Physiol, Evanston, IL 60208 USA

[2] Northwestern Univ, Dept Biochem Mol Biol & Cell Biol, Evanston, IL 60208 USA

[3] Northwestern Univ, Howard Hughes Med Inst, Evanston, IL 60208 USA

来源：

MOLECULAR BIOSYSTEMS | 2007年 / 3卷 / 01期

关键词：

D O I：

10.1039/b611613m

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Influenza A and viruses encode minimalistic proton-selective ion channels known as A/M2 and BM2, respectively. The A/M2 channel is the target of the antiviral drug, amantadine. The structural and mechanistic aspects of proton conductance of the viral ion channels are described and the review makes a case for the development of more effective antivirals.

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页码：18 / 23

页数：6

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