Engineering herpes simplex virus vectors for gene transfer to neurons

被引：57

作者：

Fink, DJ

Glorioso, JC

机构：

[1] UNIV PITTSBURGH,SCH MED,DEPT MOL GENET & BIOCHEM,PITTSBURGH,PA 15261

[2] UNIV PITTSBURGH,SCH MED,DEPT NEUROL,PITTSBURGH,PA 15261

[3] VET ADM MED CTR,PITTSBURGH,PA 15261

来源：

NATURE MEDICINE | 1997年 / 3卷 / 03期

关键词：

D O I：

10.1038/nm0397-357

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

HSV has a unique relationship with neurons which the virus naturally utilizes for efficient gene transfer and long-term gene expression. Progress in developing defective viral mutants with reduced cytotoxicity, and increasing insight into the state of the viral genome during latency and the functional elements of the latency promoter system, suggest that HSV vectors may be developed in which these natural features are exploited for effective transgene expression in brain.

引用

收藏

页码：357 / 359

页数：3

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