Effect of azithromycin plus rifampin versus amoxicillin alone on eradication and inflammation in the chronic course of Chlamydia pneumoniae pneumonitis in mice

被引：22

作者：

Bin, XX

Wolf, K

Schaffner, T

Malinverni, R

机构：

[1] Univ Bern, Inselspital, Dept Clin Res, CH-3010 Bern, Switzerland

[2] Univ Bern, Inselspital, Inst Pathol, CH-3010 Bern, Switzerland

[3] Univ Bern, Inselspital, Med Policlin, CH-3010 Bern, Switzerland

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2000年 / 44卷 / 06期

关键词：

D O I：

10.1128/AAC.44.6.1761-1764.2000

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The effects of treatment with azithromycin plus rifampin (A+R), amoxicillin (A), or placebo (P) on the chronic course of experimental Chlamydia pneumoniae pneumonitis in mice were assessed by culture, PCR, and immunocytochemistry as well as by degree of inflammation in lung tissue. Eradication of the pathogen was significantly more frequent and inflammation in tissue was significantly reduced after treatment with A+R compared to after treatment with A or P. Combination therapy with azithromycin plus rifampin showed favorable effects in the chronic course of C. pneumoniae pneumonitis.

引用

页码：1761 / 1764

页数：4

共 23 条

[1] Randomized secondary prevention trial of azithromycin in patients with coronary artery disease and serological evidence for Chlamydia pneumoniae infection -: The azithromycin in coronary artery disease:: Elimination of myocardial infection with Chlamydia (ACADEMIC) study [J].