Efficacy of FK463, a (1,3)-β-D-glucan synthase inhibitor, in disseminated azole-resistant Candida albicans infection in mice

被引：59

作者：

Maesaki, S ^{[1
]}

Hossain, MA ^{[1
]}

Miyazaki, Y ^{[1
]}

Tomono, K ^{[1
]}

Tashiro, T ^{[1
]}

Kohno, S ^{[1
]}

机构：

[1] Nagasaki Univ, Sch Med, Dept Internal Med 2, Nagasaki 8528501, Japan

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2000年 / 44卷 / 06期

关键词：

D O I：

10.1128/AAC.44.6.1728-1730.2000

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The efficacy of FK463, a new (1,3)-beta-D-glucan synthase inhibitor, against azole-resistant Candida albicans strains has been studied. The MIC of FK463 nas lo,ver than those of azoles and amphotericin B against CDR1-expressing C26 and CaMDR-expressing C40 strains. All mice treated with FK463 (1 mg/kg) survived disseminated murine candidiasis. The fungal burden in the kidney after 6 days was markedly reduced after therapy with FK463 and amphotericin B sodium deoxyholate, and plasma (1,3)-beta-D-glucan concentration was found to be lower in FK463-treated mice. In our study, FK463 was found to be a potent antifungal agent against disseminated infection with azole-resistant C. albicans.

引用

页码：1728 / 1730

页数：3

共 16 条

[1] Multiple efflux mechanisms are involved in Candida albicans fluconazole resistance
Albertson, GD
Niimi, M
Cannon, RD
Jenkinson, HF
[J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1996, 40 (12) : 2835 - 2841
[2] Hossain MA, 1997, J CLIN LAB ANAL, V11, P73, DOI 10.1002/(SICI)1098-2825(1997)11:2&lt
[3] 73::AID-JCLA1&gt
[4] 3.0.CO
[5] 2-L
[6] AEROSOL AND PARENTERAL PNEUMOCANDINS ARE EFFECTIVE IN A RAT MODEL OF PULMONARY ASPERGILLOSIS
KURTZ, MB
BERNARD, EM
EDWARDS, FF
MARRINAN, JA
DROPINSKI, J
DOUGLAS, CM
ARMSTRONG, D
[J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1995, 39 (08) : 1784 - 1789
[7] HIGH PREVALENCE OF ANTIFUNGAL RESISTANCE IN CANDIDA SPP FROM PATIENTS WITH AIDS
LAW, D
MOORE, CB
WARDLE, HM
GANGULI, LA
KEANEY, MGL
DENNING, DW
[J]. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1994, 34 (05) : 659 - 668
[8] Synergic effects of tacrolimus and azole antifungal agents against azole-resistant Candida albicans strains
Maesaki, S
Marichal, P
Hossain, MA
Sanglard, D
Vander Bossche, H
Kohno, S
[J]. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1998, 42 (06) : 747 - 753
[9] PLASMA (1-]3)-BETA-D-GLUCAN AND FUNGAL ANTIGENEMIA IN PATIENTS WITH CANDIDEMIA, ASPERGILLOSIS, AND CRYPTOCOCCOSIS
MIYAZAKI, T
KOHNO, S
MITSUTAKE, K
MAESAKI, S
TANAKA, KI
ISHIKAWA, N
HARA, K
[J]. JOURNAL OF CLINICAL MICROBIOLOGY, 1995, 33 (12) : 3115 - 3118
[10] *NAT COMM CLIN LAB, 1997, M2MA NAT COMM CLIN L

← 1 2 →