Preparation and Characterization of n-Hydroxyapatite/PCL-Pluronic-PCL Nanocomposites for Tissue Engineering

被引：25

作者：

Fu, Shaozhi ^{[1
]}

Guo, Gang ^{[1
]}

Wang, Xinlong ^{[2
]}

Zhou, Liangxue ^{[1
]}

Liu, Tingting ^{[1
]}

Dong, Pengwei ^{[1
]}

Luo, Feng ^{[1
]}

Gu, Yingchun ^{[1
]}

Shi, Xingyu ^{[1
]}

Zhao, Xia ^{[1
]}

Wei, Yuquan ^{[1
]}

Qian, Zhiyong ^{[1
]}

机构：

[1] Sichuan Univ, State Key Lab Biotherapy, W China Hosp, W China Med Sch, Chengdu 610041, Peoples R China

[2] Sichuan Univ, Coll Chem Engn, Chengdu 610065, Peoples R China

来源：

JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY | 2010年 / 10卷 / 02期

关键词：

n-Hydroxyapatite; PCL-Pluronic-PCL; Block Copolymer; Nanocomposites; In-Situ Combination; EPSILON-CAPROLACTONE; COMPOSITE SCAFFOLDS; IN-VITRO; BONE; POLYLACTIDE; COPOLYMERS; DESIGN;

D O I：

10.1166/jnn.2010.1888

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

In this paper, a new kind of polymeric nanocomposite materials based on nano-hydroxyapatite (n-HA) and PCL-Pluronic-PCL (PCFC) copolymer were prepared by in situ combination method. Firstly, the PCFC copolymer was synthesized by ring-opening polymerization of e-caprolactone initiated by Pluronic (PEG-PPG-PEG); Secondly, n-HA powder were combined with PCFC to form polymeric composites in the presence of hexamethylene diisocyanate (HDI). The obtained composites were characterized by H-1-NMR, FTIR, XRD, TEM, SEM, DTA/TGA, and tensile testing. The results revealed that n-HA could be dispersed into polymer matrix uniformly, and the n-HA/PCFC composite showed great mechanical properties when the content of n-HA was 10 wt%. The microstructure and thermal properties of the composites were discussed in the paper too. The experimental results suggested that this polymeric nanocomposite might have great potential application in the field of tissue engineering.

引用

页码：711 / 718

页数：8

共 41 条

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