Synthesis of the methyl glycoside of a branched octasaccharide fragment specific for the Shigella flexneri serotype 2a O-antigen

被引：15

作者：

Bélot, F

Costachel, C

Wright, K

Phalipon, A

Mulard, LA ^{[1
]}

机构：

[1] Inst Pasteur, Unite Chim Organ, CNRS, URA 2128, 28 Rue Dr Roux, F-75724 Paris 15, France

[2] Inst Pasteur, Unite Pathogenie Microbienne Mol, INSERM, U 389, F-75724 Paris 15, France

来源：

TETRAHEDRON LETTERS | 2002年 / 43卷 / 46期

关键词：

bacterial oligosaccharides; Shigella flexneri; chemical glycosylation;

D O I：

10.1016/S0040-4039(02)02055-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient synthesis of the methyl glycoside of a branched octasaccharide representative of Shigella flexneri serotype 2a O-specific polysaccharide is described. The synthesis is based on the use of the trichloroacetimidate methodology, and involves the condensation of a pentasaccharide acceptor and a trisaccharide donor as the key step. (C) 2002 Elsevier Science Ltd. All rights reserved.

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页码：8215 / 8218

页数：4

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