Transforming growth factor-β:: innately bipolar

被引：140

作者：

Wahl, Sharon M. ^{[1
]}

机构：

[1] NIDCR, Oral Infect & Immun Branch, NIH, Bethesda, MD 20892 USA

来源：

CURRENT OPINION IN IMMUNOLOGY | 2007年 / 19卷 / 01期

关键词：

D O I：

10.1016/j.coi.2006.11.008

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Widely heralded for depressing ongoing immune responses, renewed interest in the proficiency by which transforming growth factor beta (TGF-beta) not only engages but also might drive an over-reactive innate response highlights its bipolar nature. Although coordination of the development and function of Treg, in addition to direct inhibition of cellular activation, are prominent pathways by which TGF-beta controls adaptive immunity, paradoxically TGF-beta appears instrumental in initiation of host responses to invasion through recruitment and activation of immune cells and persuasion of Th17 lineage commitment. Nevertheless, true to its manic-depressive behavior, new evidence links TGF-beta with depression of innate cells, including INK cells, and by way of a potential bridge between mast cells and Treg. Disruption of the tenuous balance between these opposing actions of TGF-beta underlies immunopathogenicity.

引用

页码：55 / 62

页数：8

共 52 条

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