Well-differentiated and dedifferentiated liposarcomas

被引：180

作者：

Coindre, Jean-Michel ^{[1
,2
,3
]}

Pedeutour, Florence ^{[4
,5
]}

Aurias, Alain ^{[6
]}

机构：

[1] Inst Bergonie, Dept Pathol, F-33076 Bordeaux, France

[2] Inst Bergonie, INSERM, U916, F-33076 Bordeaux, France

[3] Univ Victor Segalen, Pathol Lab, Bordeaux, France

[4] CHU Nice, Lab Genet Somat Tumeurs Solides, Nice, France

[5] Fac Med Nice, CNRS, UMR 6543, Nice, France

[6] Inst Curie, INSERM, U830, Paris, France

来源：

VIRCHOWS ARCHIV | 2010年 / 456卷 / 02期

关键词：

Well-differentiated liposarcoma; Dedifferentiated liposarcoma; MDM2; CDK4; MALIGNANT FIBROUS HISTIOCYTOMAS; DIVERGENT MYOSARCOMATOUS DIFFERENTIATION; IN-SITU HYBRIDIZATION; SOFT-TISSUE; CLINICOPATHOLOGICAL ANALYSIS; RETROPERITONEAL LIPOSARCOMA; MARKER CHROMOSOMES; ATYPICAL LIPOMA; MDM2; AMPLIFICATION;

D O I：

10.1007/s00428-009-0815-x

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Atypical lipomatous tumor or well-differentiated liposarcoma (ALT-WDLPS) and dedifferentiated liposarcoma (DDLPS) share the same basic genetic abnormality characterized by a simple genomic profile with a 12q14-15 amplification involving MDM2 gene. These tumors are the most frequent LPS. This paper reviews the molecular pathology, general clinical and imaging features, histopathology, new diagnostic tools, and prognosis of ALT-WDLPS and DDLPS.

引用

页码：167 / 179

页数：13

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