Incorporation of phenethylisoquinolines into colchicine in isolated seeds of Colchicum autumnale

被引：14

作者：

Nasreen, A ^{[1
]}

Gundlach, H ^{[1
]}

Zenk, MH ^{[1
]}

机构：

[1] UNIV MUNICH,LEHRSTUHL PHARMAZEUT BIOL,D-80333 MUNICH,GERMANY

来源：

PHYTOCHEMISTRY | 1997年 / 46卷 / 01期

关键词：

Colchicum autumnale; Liliaceae; autumnaline; biosynthesis; colchicine; isoandrocymbine; phenethylisoquinoline;

D O I：

10.1016/S0031-9422(97)00242-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The physiological parameters for application experiments using immature seeds of Colchicum autumnale were optimized, so that incorporation rates in the range of 10% and higher were consistently obtained with intermediate precursors. Application of tritium and C-13-labelled phenethylisoquinolines showed that N-methylation occurs prior to the substitution of ring C and that the free hydroxy group in position 13 of autumnaline is necessary for the phenolic coupling reaction. Autumnaline gives rise to a vast array of metabolites in seeds of this plant. (C) 1997 Published by Elsevier Science Ltd. All rights reserved.

引用

页码：107 / 115

页数：9

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