PECAM-1 expression and activity negatively regulate multiple platelet signaling pathways

被引：28

作者：

Jones, Chris I. ^{[1
]}

Garner, Stephen F. ^{[2
,3
]}

Moraes, Leonardo A. ^{[1
]}

Kaiser, William J. ^{[1
]}

Rankin, Angela ^{[2
,3
]}

Ouwehand, Willem H. ^{[2
,3
,4
]}

Goodall, Alison H. ^{[5
]}

Gibbins, Jonathan M. ^{[1
]}

机构：

[1] Univ Reading, Sch Biol Sci, Inst Cardiovasc & Metab Res, Reading RG6 6UB, Berks, England

[2] Univ Cambridge, Dept Haematol, Cambridge, England

[3] NHS Blood & Transplant, Cambridge, England

[4] Wellcome Trust Sanger Inst, Dept Human Genet, Cambridge, England

[5] Univ Leicester, Leicester LE1 7RH, Leics, England

来源：

FEBS LETTERS | 2009年 / 583卷 / 22期

关键词：

Platelets; PECAM-1; Collagen; ADP; Thrombin; Thrombus; CELL-ADHESION MOLECULE-1; PROTEIN-TYROSINE-PHOSPHATASE; TRANSENDOTHELIAL MIGRATION; INTEGRIN ACTIVATION; THROMBUS FORMATION; COLLAGEN; SHP-2; AGGREGATION; RECEPTOR; CD31;

D O I：

10.1016/j.febslet.2009.10.037

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Platelet endothelial cell adhesion molecule-1 (PECAM-1) inhibits platelet response to collagen and may also inhibit two other major platelet agonists ADP and thrombin although this has been less well explored. We hypothesized that the combined effect of inhibiting these three platelet activating pathways may act to significantly inhibit thrombus formation. We demonstrate a negative relationship between PECAM-1 surface expression and platelet response to cross-linked collagen related peptide (CRP-XL) and ADP, and an inhibitory effect of PECAM-1 clustering on platelet response to CRP-XL, ADP and thrombin. This combined inhibition of multiple signaling pathways results in a marked reduction in thrombus formation. (C) 2009 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.

引用

页码：3618 / 3624

页数：7

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