Cytoskeleton out of the cupboard:: colon cancer and cytoskeletal changes induced by loss of APC

被引：96

作者：

Nathke, Inke ^{[1
]}

机构：

[1] Univ Dundee, Div Cell & Dev Biol, Dundee DD1 5EH, Scotland

来源：

NATURE REVIEWS CANCER | 2006年 / 6卷 / 12期

关键词：

D O I：

10.1038/nrc2010

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Mutation of APC (adenomatous polyposis coli) is a common factor in most colorectal cancers. APC has many functions, the most prominent is its capacity to regulate beta-catenin-mediated gene transcription in response to Wnt signalling. Loss of APC leads to deregulated beta-catenin and this is intimately linked with tumour formation. However, recent evidence indicates that the interaction of APC with the cytoskeleton might also contribute to tumour initiation and progression. How does APC interact with the cytoskeleton and how could this play a part in colorectal tumorigenesis?

引用

页码：967 / 974

页数：9

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