Purine phosphoribosyltransferases

被引：93

作者：

Craig, SP ^{[1
]}

Eakin, AE ^{[1
]}

机构：

[1] Univ N Carolina, Sch Pharm, Lab Mol Parasitol & Drug Design, Chapel Hill, NC 27599 USA

来源：

JOURNAL OF BIOLOGICAL CHEMISTRY | 2000年 / 275卷 / 27期

关键词：

D O I：

10.1074/jbc.R000002200

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

引用

页码：20231 / 20234

页数：4

共 39 条

[1]

Rational design of selective submicromolar inhibitors of Tritrichomonas foetus hypoxanthine-guanine-xanthine phosphoribosyltransferase [J].

Aronov, AM ;

Munagala, NR ;

de Montellano, PRO ;

Kuntz, ID ;

Wang, CC .

BIOCHEMISTRY, 2000, 39 (16) :4684-4691

[2]

Ternary complex structure of human HGPRTase, PRPP, Mg2+, and the inhibitor HPP reveals the involvement of the flexible loop in substrate binding [J].

Balendiran, GK ;

Molina, JA ;

Xu, YM ;

Torres-Martinez, J ;

Stevens, R ;

Focia, PJ ;

Eakin, AE ;

Sacchettini, JC ;

Craig, SP .

PROTEIN SCIENCE, 1999, 8 (05) :1023-1031

[3]

BENNETT LL, 1985, MOL PHARMACOL, V27, P666

[4]

Berens Randolph L., 1995, P89, DOI 10.1016/B978-012473345-9/50007-6

[5]

KINETIC MECHANISM OF OROTATE PHOSPHORIBOSYLTRANSFERASE FROM SALMONELLA-TYPHIMURIUM [J].

BHATIA, MB ;

VINITSKY, A ;

GRUBMEYER, C .

BIOCHEMISTRY, 1990, 29 (46) :10480-10487

[6]

Substitution of lysine for arginine at position 199 of a hypoxanthine phosphoribosyltransferase interferes with binding of the primary substrate to the active site [J].

Craig, SP ;

Focia, PJ ;

Fletterick, RJ .

BIOCHIMICA ET BIOPHYSICA ACTA-PROTEIN STRUCTURE AND MOLECULAR ENZYMOLOGY, 1997, 1339 (01) :1-3

[7]

Purine salvage enzymes of parasites as targets for structure-based inhibitor design [J].

Craig, SP ;

Eakin, AE .

PARASITOLOGY TODAY, 1997, 13 (06) :238-241

[8]

THE CRYSTAL-STRUCTURE OF HUMAN HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE WITH BOUND GMP [J].

EADS, JC ;

SCAPIN, G ;

XU, YM ;

GRUBMEYER, C ;

SACCHETTINI, JC .

CELL, 1994, 78 (02) :325-334

[9]

Approaching the transition state in the crystal structure of a phosphoribosyltransferase [J].

Focia, PJ ;

Craig, SP ;

Eakin, AE .

BIOCHEMISTRY, 1998, 37 (49) :17120-17127

[10]

A 1.4 Å crystal structure for the hypoxanthine phosphoribosyltransferase of Trypanosoma cruzi [J].

Focia, PJ ;

Craig, SP ;

Nieves-Alicea, R ;

Fletterick, RJ ;

Eakin, AE .

BIOCHEMISTRY, 1998, 37 (43) :15066-15075

← 1 2 3 4 →