Transcription factors control invasion: AP-1 the first among equals

被引:206
作者
Ozanne, B. W.
Spence, H. J.
McGarry, L. C.
Hennigan, R. F.
机构
[1] Univ Cincinnati, Dept Cell Biol, Cincinnati, OH 45267 USA
[2] Beatson Inst Canc Res, Invas & Metastasis Lab, Glasgow G61 1BD, Lanark, Scotland
关键词
invasion; metastasis; AP-1; Fos; Jun; transcription factors;
D O I
10.1038/sj.onc.1209759
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Metastasis, the aggressive spread of a malignant tumor to distant organs, is a major cause of death in cancer patients. Despite this critical role in cancer outcomes, the molecular mechanisms that control this process are just beginning to be understood. Metastasis is largely dependent upon the ability of tumor cells to invade the barrier formed by the basement membrane and to migrate through neighboring tissues. This review will summarize the evidence that tumor cell invasion is the result of oncogene-mediated signal transduction pathways that control the expression of a specific set of genes that together mediate tumor cell invasion. We focus on the role of the transcription factor AP-1 to both induce the expression of genes that function as invasion effectors and repress other genes that function as invasion suppressors. This identies AP-1 as a critical regulator of a complex program of gene expression that de. nes the invasive phenotype.
引用
收藏
页码:1 / 10
页数:10
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