Anti-arthritic activity of a biopolymeric fraction from Euphorbia tirucalli

被引：36

作者：

Bani, Sarang

Kaul, Anpurna

Khan, Beenish

Gupta, Vijay Kumar

Satti, Naresh Kumar

Suri, Krishan Avtar

Qazi, Ghulam Nabi

机构：

[1] Reg Res Lab, Dept Pharmacol, Jammu 180001, JK, India

[2] Reg Res Lab, Nat Prod Chem Div, Jammu 180001, JK, India

来源：

JOURNAL OF ETHNOPHARMACOLOGY | 2007年 / 110卷 / 01期

关键词：

Euphorbia tirucalli; immunosuppressive; arthritis; flowcytometry; intracellular; IL-2; IFN-gamma;

D O I：

10.1016/j.jep.2006.09.021

中图分类号：

Q94 [植物学];

学科分类号：

071001 [植物学];

摘要：

The present study was undertaken to investigate the anti-arthritic activity of a biopolymeric fraction (BET) from plant Euphorbia tirucalli Boiss (Euphorbiaceae). The fraction showed dose dependent anti-arthritic activity and also showed in vivo immunomodulatory capacity being a major component in inhibiting arthritis. It caused suppression of CD4(+) and CD8(+) T cells, inhibition of intracellular Interleukin-2 (IL-2) and Interferon-gamma (IFN-gamma) by flowcytometry. It inhibited vascular permeability and the migration of leucocytes at the site of the insult. The oral LD0 in both rats and mice was more than 2000 mg/kg. (c) 2006 Elsevier Ireland Ltd. All rights reserved.

引用

页码：92 / 98

页数：7

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