A pan-cancer single-cell transcriptional atlas of tumor infiltrating myeloid cells

被引：983

作者：

Cheng, Sijin ^{[1
]}

Li, Ziyi ^{[1
]}

Gao, Ranran ^{[1
]}

Xing, Baocai ^{[2
]}

Gao, Yunong ^{[3
]}

Yang, Yu ^{[1
]}

Qin, Shishang ^{[1
]}

Zhang, Lei ^{[1
]}

Ouyang, Hanqiang ^{[4
]}

Du, Peng ^{[5
]}

Jiang, Liang ^{[4
]}

Zhang, Bin ^{[6
]}

Yang, Yue ^{[7
]}

Wang, Xiliang ^{[1
]}

Ren, Xianwen ^{[1
]}

Bei, Jin-Xin ^{[8
]}

Hu, Xueda ^{[1
]}

Bu, Zhaode ^{[9
]}

Ji, Jiafu ^{[10
]}

Zhang, Zemin ^{[1
,11
,12
]}

机构：

[1] Peking Univ, Beijing Adv Innovat Ctr Genom, Sch Life Sci, BIOPIC, Beijing 100871, Peoples R China

[2] Peking Univ, Dept Hepatopancreatobiliary Surg 1, Key Lab Carcinogenesis & Translat Res Minist Educ, Canc Hosp & Inst, Beijing 100142, Peoples R China

[3] Peking Univ, Dept Gynecol Oncol, Key Lab Carcinogenesis & Translat Res Minist Educ, Canc Hosp & Inst, Beijing 100142, Peoples R China

[4] Peking Univ, Dept Orthopaed, Beijing Key Lab Spinal Dis Res, Hosp 3, Beijing 100191, Peoples R China

[5] Peking Univ, Dept Urol, Key Lab Carcinogenesis & Translat Res Minist Educ, Canc Hosp & Inst, Beijing 100142, Peoples R China

[6] Peking Univ, Dept Head & Neck Surg, Key Lab Carcinogenesis & Translat Res Minist Educ, Canc Hosp & Inst, Beijing 100142, Peoples R China

[7] Peking Univ, Dept Thorac Surg 2, Key Lab Carcinogenesis & Translat Res, Canc Hosp & Inst,Minist Educ, Beijing 100142, Peoples R China

[8] Sun Yat Sen Univ, Collaborat Innovat Ctr Canc Med,Minist Educ, State Key Lab Oncol South China,Canc Ctr, Guangdong Key Lab Nasopharyngeal Carcinoma Diag &, Guangzhou 510060, Peoples R China

[9] Peking Univ, Dept Gastrointestinal Surg, Key Lab Carcinogenesis & Translat Res, Minist Educ,Canc Hosp & Inst, Beijing 100142, Peoples R China

[10] Peking Univ, Key Lab Carcinogenesis & Translat Res, Dept Gastrointestinal Surg, Dept Biobank,Canc Hosp & Inst,Minist Educ, Beijing 100142, Peoples R China

[11] Inst Canc Res, Shenzhen Bay Lab, Shenzhen 518132, Peoples R China

[12] Peking Univ, Int Canc Inst, Beijing 100191, Peoples R China

来源：

CELL | 2021年 / 184卷 / 03期

基金：

北京市自然科学基金; 中国国家自然科学基金;

关键词：

DENDRITIC CELLS; MAST-CELLS; LANGERHANS CELLS; T-CELLS; ACTIVATION; TARGET; PD-L1; QUANTIFICATION; IMMUNOTHERAPY; EXPRESSION;

D O I：

10.1016/j.cell.2021.01.010

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Tumor-infiltrating myeloid cells (TIMs) are key regulators in tumor progression, but the similarity and distinction of their fundamental properties across different tumors remain elusive. Here, by performing a pan-cancer analysis of single myeloid cells from 210 patients across 15 human cancer types, we identified distinct features of TIMs across cancer types. Mast cells in nasopharyngeal cancer were found to be associated with better prognosis and exhibited an anti-tumor phenotype with a high ratio of TNF+/VEGFA(+) cells. Systematic comparison between cDC1- and cDC2-derived LAMP3(+) cDCs revealed their differences in transcription factors and external stimulus. Additionally, pro-angiogenic tumor-associated macrophages (TAMs) were characterized with diverse markers across different cancer types, and the composition of TIMs appeared to be associated with certain features of somatic mutations and gene expressions. Our results provide a systematic view of the highly heterogeneous TIMs and suggest future avenues for rational, targeted immunotherapies.

引用

页码：792 / +

页数：41

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