Infections in IFNGR-1-deficient children

被引：60

作者：

Jouanguy, E ^{[1
]}

Altare, F ^{[1
]}

LamhamediCherradi, S ^{[1
]}

Casanova, JL ^{[1
]}

机构：

[1] HOP NECKER ENFANTS MALAD,INSERM,U429,F-75015 PARIS,FRANCE

来源：

JOURNAL OF INTERFERON AND CYTOKINE RESEARCH | 1997年 / 17卷 / 10期

关键词：

D O I：

10.1089/jir.1997.17.583

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Human interferon-gamma receptor 1 (IFNGR-1) deficiency is a newly identified autosomal recessive inherited immune disorder. Children with IFNGR-1 deficiency exhibit a severe, profound and selective susceptibility to weakly virulent mycobacteria, such as bacillus Calmette-Guerin (BCG) vaccine or environmental nontuberculous mycobacteria (NTM), This review compares the infections found in IFNGR-1-deficient children to those in IFN-gamma-deficient or IFNGR-1-deficient mice.

引用

页码：583 / 587

页数：5

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