Role of epigallocatechin gallate (EGCG) in the treatment of breast and prostate cancer

被引：151

作者：

Stuart, Emma C. ^{[1
]}

Scandlyn, Marissa J. ^{[1
]}

Rosengren, Rhonda J. ^{[1
]}

机构：

[1] Univ Otago, Dept Pharmacol & Toxicol, Dunedin, New Zealand

来源：

LIFE SCIENCES | 2006年 / 79卷 / 25期

关键词：

epigallocatechin gallate; EGFR; prostate cancer; breast cancer; apoptosis;

D O I：

10.1016/j.lfs.2006.07.036

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Green tea and its major constituent epigallocatechin gallate (EGCG) have been extensively studied as a potential treatment for a variety of diseases, including cancer. Epidemiological data have suggested that EGCG may provide protective effects against hormone related cancers, namely breast or prostate cancer. Extensive in vitro investigations using both hormone responsive and non-responsive cell lines have shown that EGCG induces apoptosis and alters the expression of cell cycle regulatory proteins that are critical for cell survival and apoptosis. This review will highlight the important in vitro mechanistic actions elicited by EGCG in various breast and prostate cancer cell lines. Additionally, the actions of green tea/EGCG in in vivo models for these cancers as well as in clinical trials will be discussed. (c) 2006 Elsevier Inc. All rights reserved.

引用

页码：2329 / 2336

页数：8

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