Hepatitis B virus induced hepatocellular carcinoma

被引:147
作者
Chemin, I. [1 ]
Zoulim, F.
机构
[1] INSERM, U871, F-69003 Lyon, France
关键词
Hepatitis B; Occult infections; Natural history; Hepatocellularcinoma; UNFOLDED PROTEIN RESPONSE; OCCULT HBV INFECTION; SURFACE-ANTIGEN; MOLECULAR EPIDEMIOLOGY; ANTIVIRAL THERAPY; OXIDATIVE STRESS; UNKNOWN ETIOLOGY; TRANSGENIC MICE; LIVER-DISEASE; RISK-FACTOR;
D O I
10.1016/j.canlet.2008.12.003
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
A number of risk factors appear to play a role in Hepatocellularcinoma (HCC), HBV infection being one of the most important. Chronic inflammation and cytokines are key determinants in the development of fibrosis and liver cell proliferation. HBV DNA integration and/or expression of HBV proteins may have a direct effect on cellular functions. Occult hepatitis B virus infection is characterized by persistence of HBV DNA in hepatitis B surface antigen-negative individuals. There are evidences that occult HBV is a risk factor for the development of HCC and that the potential mechanisms whereby overt HBV might induce tumour formation are mostly maintained. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码:52 / 59
页数:8
相关论文
共 59 条
[1]   HEPATOCYTE LOCALIZATION OF HEPATITIS-B CORE AND SURFACE-ANTIGENS IN RENAL-TRANSPLANT RECIPIENTS - AN ULTRASTRUCTURAL PROSPECTIVE-STUDY [J].
AMAT, D ;
CAMILLERI, JP ;
FELDMANN, G ;
BLOCH, F ;
DUBOUST, A ;
BEDROSSIAN, J .
VIRCHOWS ARCHIV A-PATHOLOGICAL ANATOMY AND HISTOPATHOLOGY, 1981, 391 (02) :153-163
[2]   Genotype H: a new Amerindian genotype of hepatitis B virus revealed in Central America [J].
Arauz-Ruiz, P ;
Norder, H ;
Robertson, BH ;
Magnius, LO .
JOURNAL OF GENERAL VIROLOGY, 2002, 83 :2059-2073
[3]   Inflammation and cancer: back to Virchow? [J].
Balkwill, F ;
Mantovani, A .
LANCET, 2001, 357 (9255) :539-545
[4]   Pathological and virological findings in patients with persistent hypertransaminasaemia of unknown aetiology [J].
Berasain, C ;
Betés, M ;
Panizo, A ;
Ruiz, J ;
Herrero, JI ;
Civeira, MP ;
Prieto, J .
GUT, 2000, 47 (03) :429-435
[5]  
Borzio M, 1998, J CLIN PATHOL-MOL PA, V51, P96
[6]   The enigmatic X gene of hepatitis B virus [J].
Bouchard, MJ ;
Schneider, RJ .
JOURNAL OF VIROLOGY, 2004, 78 (23) :12725-12734
[7]   Altered expression of hepatic carcinogen metabolizing enzymes with liver injury in HBV transgenic mouse lineages expressing various amounts of hepatitis B surface antigen [J].
Chemin, I ;
Ohgaki, H ;
Chisari, FV ;
Wild, CP .
LIVER, 1999, 19 (02) :81-87
[8]   High incidence of hepatitis B infections among chronic hepatitis cases of unknown aetiology [J].
Chemin, I ;
Zoulim, F ;
Merle, P ;
Arkhis, A ;
Chevallier, M ;
Kay, A ;
Cova, L ;
Chevallier, P ;
Mandrand, B ;
Trépo, C .
JOURNAL OF HEPATOLOGY, 2001, 34 (03) :447-454
[9]   Risk of hepatocellular carcinoma across a biological gradient of serum hepatitis B virus DNA level [J].
Chen, CJ ;
Yang, HI ;
Su, J ;
Jen, CL ;
You, SL ;
Lu, SN ;
Huang, GT ;
Iloeje, UH .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2006, 295 (01) :65-73
[10]  
DEODHAR KP, 1975, J CLIN PATHOL, V1, P66