Chikungunya: a bending reality

被引:76
作者
Her, Zhisheng [1 ,2 ]
Kam, Yiu-Wing [1 ]
Lin, Raymond T. P. [3 ]
Ng, Lisa F. P. [1 ,2 ]
机构
[1] ASTAR, Singapore Immunol Network, Immunos 138648, Singapore
[2] Natl Univ Singapore, Dept Biochem, Yong Loo Lin Sch Med, Singapore 117597, Singapore
[3] Minist Hlth, Communicable Dis Div, Natl Publ Hlth Lab, Singapore 169854, Singapore
关键词
Chikungunya; Arbovirus; Epidemiology; Control; SEMLIKI-FOREST-VIRUS; EQUINE ENCEPHALOMYELITIS VIRUS; REUNION ISLAND OUTBREAK; DC-SIGN; AEDES-ALBOPICTUS; INDIAN-OCEAN; MONOCLONAL-ANTIBODIES; ENCEPHALITIS-VIRUS; EPIDEMIC OUTBREAK; E2; GLYCOPROTEIN;
D O I
10.1016/j.micinf.2009.09.004
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Chikungunya fever is an acute illness caused by the arbovirus Chikungunya virus. The virus is transmitted primarily in a sylvatic cycle involving the Aedes mosquitoes. Since 2005, a Chikungunya fever outbreak of unprecedented magnitude occurred on several Indian Ocean islands. Since then, the disease has spread to many parts of the world due to imported cases among travellers returning from epidemic areas. Chikungunya virus causes a wide spectrum of illness including fever, a characteristic rash, disabling joint symptoms which can sometimes become severe that lasts months. This review summarises on this history of Chikungunya fever, host specificity, the characteristics of Chikungunya virus, clinical features of disease and current control measures. It focuses on how the re-emergence of an old changed the outlook of managing arboviral diseases in the present social and public health context. (C) 2009 Elsevier Masson SAS. All rights reserved.
引用
收藏
页码:1165 / 1176
页数:12
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