The molecular pathogenesis of collagen-induced arthritis in mice -: a model for rheumatoid arthritis

被引：160

作者：

Holmdahl, R ^{[1
]}

Bockermann, R ^{[1
]}

Bäcklund, J ^{[1
]}

Yamada, H ^{[1
]}

机构：

[1] Lund Univ, Sect Med Inflammat Res, S-22184 Lund, Sweden

来源：

AGEING RESEARCH REVIEWS | 2002年 / 1卷 / 01期

关键词：

rheumatoid arthritis; collagen indiced arthritis; type II collagen; cartilage; autoimmunity;

D O I：

10.1016/S0047-6374(01)00371-2

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 [细胞生物学]; 090102 [作物遗传育种];

摘要：

The most widely used model for rheumatoid arthritis is the collagen-induced arthritis (CIA) in mice. This model has gained acceptance since it is reproducible, well defined and has proven useful for development of new therapies for rheumatoid arthritis, as exemplified by the most recent advancement using TNFalpha neutralization treatment. The collagen-induced arthritis model, however, represents only certain pathways leading to arthritis and there is no consensus on how they operate. Nevertheless, we are beginning to understand the immune recognition structures, such as MHC molecules, lymphocyte receptors and type II collagen epitopes, which are of crucial importance for the development of this disease. These provide useful tools for further investigations of the pathogenesis of CIA as well as for understanding the pathogenesis of rheumatoid arthritis. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：135 / 147

页数：13

共 52 条

[1]

Definition of MHC and T cell receptor contacts in the HLA-DR4-restricted immunodominant epitope in type II collagen and characterization of collagen-induced arthritis in HLA-DR4 and human CD4 transgenic mice [J].