Valvular heart disease in a patient taking benfluorex

被引:35
作者
Noize, P.
Sauer, M.
Bruneval, P.
Moreau, M.
Pathak, A.
Bagheri, H.
Montastruc, J. L.
机构
[1] Univ Toulouse 3, Fac Med, CHU,Serv Pharmacol Clin, Ctr Midi Pyrenees Pharmaco Vigilance Pharmacoepid, F-31000 Toulouse, France
[2] Clin Pasteur, Serv Chirurg Cardiaque, Toulouse, France
[3] Hop Europeen Georges Pompidou, Serv Anat Pathol, Paris, France
[4] Anat & Cytol Pathol, Toulouse, France
关键词
adverse drug reaction; amphetamines; benfluorex; pharmacovigilance; valvular heart disease;
D O I
10.1111/j.1472-8206.2006.00441.x
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The authors describe a case of valvular heart disease in a 48-year-old woman receiving benfluorex (1.50 mg t.i.d. for 8 years) and leading to surgical mitral valve replacement. Examination showed severe dyspnea with severe mitral regurgitation associated with tricuspid regurgitation. No other common disease known to affect mitral valves nor intake of other drugs (ergot derivatives or appetite suppressant drugs) was found. The paper discusses the imputability of benfluorex, a drug used as an adjuvant in hypercholesterolemia, structurally related to amphetamines.
引用
收藏
页码:577 / 578
页数:2
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