Two-month effects of individualized exercise training with or without caloric restriction on plasma adipocytokine levels in obese female adolescents

Objectives. - To examine if, in young obese patients, an individualized training programme in association with a caloric restriction programme which had an effect on whole-body lipid oxidation, was able to induce changes on plasma adipocytokine concentrations. Materials and methods. Twenty-seven obese female adolescents participated in the study. Whole-body lipid oxidation during exercise was assessed by indirect calorimetry during a graded cycle ergometer test. Body mass (BM), body mass index (BMI), percentage of body fat (%BF), insulin homeostasis model assessment (HOMA-IR) and fasting levels of circulating adipocytokines were assessed prior and after a two-month diet programme, individualized training programme targeted at Lipox(max) corresponded to the power at which the highest rate of lipids was oxidized and combined diet/training programme.Results. - The diet/training programme induced both a shift to a higher-power intensity of Lipox(max) (+27.8 +/- 5.1 W;p<0.01) and an increase of lipid oxidation at Lipox(max) (+96.8 +/- 16.2 mg/min; p<0.01). The enhancement in lipid oxidation was significantly (p<0.01) correlated with the diet/training-induced improvement in %BF(r=-0.47),HOMA-IR(r=-0.66), leptin (r=-0.41),TNF-alpha (r=-0.48), IL-6 (r=-0.38), adiponectin (r=0.43) and resistin (r=0.51). Conclusion. - This study showed that in obese female adolescents a moderate training protocol targeted at Lipox(max) and combined with a diet programme improved their ability to oxidize lipids during exercise, and that this improvement was associated with changes in plasma adipocytokine concentrations. (C) 2009 Elsevier Masson SAS. All rights reserved.