A simple linker for the attachment of aldehydes to the solid phase. Application to solid phase synthesis by the Multipin(TM) method.

被引：53

作者：

Ede, NJ ^{[1
]}

Bray, AM ^{[1
]}

机构：

[1] CHIRON TECHNOL PTY LTD,CLAYTON,VIC 3168,AUSTRALIA

来源：

TETRAHEDRON LETTERS | 1997年 / 38卷 / 40期

关键词：

D O I：

10.1016/S0040-4039(97)01635-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A simple linker has been developed for the attachment of aldehyde functionality. The aldehyde substrate is condensed with a support-bound serine or threonine to give an oxazolidine. The oxazolidine linker is stable to the conditions of Fmoc peptide synthesis, including TFA treatment, but is cleaved by mild aqueous acid at 60 degrees C. The method is used, in conjunction with the Multipin method, to prepare a set of peptide aldehydes. (C) 1997 Elsevier Science Ltd.

引用

页码：7119 / 7122

页数：4

共 17 条

[1] PREPARATION AND APPLICATION OF THE 5-(4-(9-FLUORENYLMETHYLOXYCARBONYL)AMINOMETHYL-3,5-DIMETHOXYPHENOXY)VALERIC ACID (PAL) HANDLE FOR THE SOLID-PHASE SYNTHESIS OF C-TERMINAL PEPTIDE AMIDES UNDER MILD CONDITIONS [J].