Cholestane glycosides with potent cytostatic activities on various tumor cells from Ornithogalum saundersiae bulbs

被引：176

作者：

Mimaki, Y

Kuroda, M

Kameyama, A

Sashida, Y

Hirano, T

Oka, K

Maekawa, R

Wada, T

Sugita, K

Beutler, JA

机构：

[1] SHIONOGI & CO LTD, DISCOVERY RES LABS 2, DEPT CELL INFORMAT, FUKUSHIMA KU, OSAKA 553, JAPAN

[2] NCI, FREDERICK CANC RES & DEV CTR, LAB DRUG DISCOVERY RES & DEV, DEV THERAPEUT PROGRAM, FREDERICK, MD 21702 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1997年 / 7卷 / 05期

关键词：

D O I：

10.1016/S0960-894X(97)00071-1

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Five cholestane glycosides (1 - 5) including three new ones (3 - 5) with potent cytostatic activity on leukemia HL-60 cells were isolated from Ornithogalum saundersiae bulbs. Compound 1, a main constituent in the bulbs, was revealed to be exceptionally cytostatic against various malignant tumor cells and effective to mouse P388 leukemia in in vivo evaluation. (C) 1997 Elsevier Science Ltd. All rights reserved.

引用

页码：633 / 636

页数：4

共 6 条

[1] SOME PRACTICAL CONSIDERATIONS AND APPLICATIONS OF THE NATIONAL-CANCER-INSTITUTE IN-VITRO ANTICANCER DRUG DISCOVERY SCREEN [J].